Cytosine CAS:71-30-7 C4H5N3O
| Nomoro ea lethathamo | XD90555 |
| Lebitso la Sehlahiswa | Cytosine |
| CAS | 71-30-7 |
| Foromo ea limolek'hule | C4H5N3O |
| Boima ba Molek'hule | 111.10 |
| Lintlha tsa polokelo | Ambient |
| Khoutu ea Lekhetho e Kopantsoeng | 29335995 |
Tlhaloso ea Sehlahisoa
| Ponahalo | Tiileng |
| Tlhahlobo | 99% |
Tet 5-methylcytosine dioxygenase e thusa DNA demethylation ka ho hlahisa 5-hydroxymethylcytosine le lihlahisoa tse ling tse nang le oxidized.Tet1 le Tet2 li hlahisoa haholo liseleng tsa pluripotent tsa mouse 'me li fokotsehile ho ea ka litekanyo tse fapaneng liseleng tsa somatic, empa mekhoa ea ho ngola ha e hlake.Mona re hlalositse libaka tsa papatso le lintlafatso ho Tet1 le Tet2.Ka har'a "superenhancer" ea 15-kb ea Tet1, ho na le libaka tse peli tse qalang tsa transcript (TSSs) tse nang le mekhoa e fapaneng ea ts'ebetso nakong ea nts'etsopele.Sebaka sa 6-kb se khothalletsang sebaka se ka holimo ho TSS ea distal se sebetsa haholo liseleng tse se nang kelello tsa pluripotent, ka boithaopo e tlaleha polelo ea Tet1 tsamaisong ea transgenic, 'me ka potlako e feta DNA methylation le ho khutsisa ka ho khetholla lisele tse nang le setso le epiblast ea tlhaho.TSS ea bobeli tlase ho noka, e amanang le mothetsi ea fokolang oa CpG-rich, e kenngoa ts'ebetsong ke motlatsi oa boahelani oa lisele tse nang le naive embryonic stem cells (ESCs) le primed epiblast-like cell (EpiLCs).Tet2 e na le CpG island p romoter e nang le ts'ebetso e ikemetseng ea pluripotency le ESC-specific distal intragenic enhancer;ea morao-rao e fokotsehile ka potlako ho li-EpiLC.Boithuto ba rona bo senola mekhoa e ikhethileng ea taolo ea mongolo ho Tet1 le Tet2 nakong ea liphetoho tsa boemo ba lisele tsa nts'etsopele ea pele.Baqolotsi ba litaba ba bacha ba transgenic ba sebelisang libaka tsa taolo ea Tet1 le Tet2 ba ka thusa ho khetholla liphetoho tse sa tšoaneng linaheng tsa pluripotent le mefuta e sa tšoaneng ea epigenetic.
