Lihlahisoa

Bopaki ba morao-rao bo tšehetsa karolo e hlahang ea β-nicotinamide adenine dinucleotide (β-NAD(+)) e le novel neurotransmitter le neuromodulator tsamaisong ea methapo ea methapo -β-NAD(+) e lokolloa litokisetsong tsa mesifa e boreleli le lisele tsa adrenal chromaffin. ka mokgwa wa sebopeho sa neurotransmitter.Hajoale ha ho hlake hore na sena ke 'nete bakeng sa CNS.Re sebelisa tlhahlobo ea superfusion ea kamore e nyane le mekhoa e matla ea "high-pressure liquid chromatography", re bonts'a hore ts'usumetso e phahameng ea K(+) ea li-synaptosomes tsa rat forebrain e tsosa ho tlala ha β-NAD(+) , adenosine 5'-triphosphate, le tsa bona. metabolites adenosine 5'-diphosphate (ADP), adenosine 5'-monophosphate, adenosine, ADP-ribose (ADPR) le cyclic ADPR.The high-K(+) -evoked overflow ea β-NAD(+) e fokotsoa ke ho petsoha ha SNAP-25 le botulinum neurotoxin A, ka ho thibela likanale tsa mofuta oa N-mofuta oa Ca(2+) tse nang le ω-conotoxin GVIA. , le ka ho thibela proton gradient ea li-synaptic vesicles tse nang le bafilo mycin A1, ho fana ka maikutlo a hore β-NAD(+) e ka 'na ea lokolloa ka vesicle exocytosis.Tlhahlobo ea Bophirimela e bontša hore CD38, protheine e sebetsang ka bongata e fetolang β-NAD(+) , e teng ho li-membrane tsa synaptosomal le cytosol.Li-synaptosomes tse sa fetoheng li theola β-NAD(+) .1,N (6) -etheno-NAD, analog ea fluorescent ea β-NAD(+) , e nkoa ke li-synaptosomes 'me ts'ebetso ena e fokotsoa ke β-NAD (+) ea sebele, empa eseng ka connexin 43 inhibitor Gap 27. Ho cortical neurons ts'ebeliso ea lehae ea β-NAD(+) e baka ka potlako Ca (2+) transients, mohlomong ka lebaka la ho phalla ha extracellular Ca(2+) .Ka hona, li-synaptosomes tsa boko ba rat li ka lokolla, tsa theola le ho nka β-NAD(+) , 'me β-NAD(+) e ka susumetsa li-neurone tsa postsynaptic, mekhoa eohle e hlokahalang bakeng sa hore ntho e nkoe e le mokhethoa oa neurotransmitter bokong.