Lihlahisoa

1. Sepheo sa thuto ena e ne e le ho hlahisa mohlala o bonolo oa pharmacokinetic-pharmacodynamic (PK-PD) o ka khethollang nako e feletseng ea liphetoho lipalong tsa liplatelete ho bolela esale pele ho qala le tekanyo ea thrombocytopenia, e fokotsang haholo tšebeliso ea lithethefatsi. anticancer agent 5-fluorouracil (5-FU), ka likhoto.2. Lipalo tsa liplatelete li ne li lekanngoa ka likhoto tse latelang tsamaiso ea methapo ea mefuta e sa tšoaneng ea 5-FU bakeng sa matsatsi a 4 ho fumana lintlha bakeng sa tlhahlobo ea mohlala oa PK-PD.Mohlala oa rona oa PK-PD o ne o e-na le mohlala oa PK oa likarolo tse peli, o nang le likarolo tse tharo tsa mohlala oa PD le li-parameter tsa 10 tsa PK-PD.3. Ka mor'a phekolo ea 5-FU, lipalo tsa platelet li fokotsehile ka nakoana ho ea boemong ba nadir, li bontšitse ho khutlela holimo ho ea holimo ho ea pele pele ho khutlela maemong a motheo.Lipalo tsa liplatelete tsa Nadir le li-rebound li fapana ho latela boemo ba AUC0-∞.Moetso oa ho qetela oa PK-PD o ile oa tsebahatsa ka nepo lintlha tsa palo ea liplatelete le liparamente tsa ho qetela tsa PD li hakantsoe ka bonnete bo phahameng.4. Mohlala ona oa PK-PD le papiso e ka emela sesebelisoa sa bohlokoa bakeng sa ho lekanya le ho bolela esale pele nako e felletseng ea liphetoho lipalong tsa lisele tsa mali, 'me e ka kenya letsoho ntlafatsong ea maano a kalafo ka 5-FU le litlhahlobo tsa li-anticancer agents tse fapaneng. tseo ho leng thata ho li hlahloba ho batho.