Uridine,2'-deoxy-5-ethynyl- Cas:61135-33-9
| Nomoro ea lethathamo | XD90589 |
| Lebitso la Sehlahiswa | Uridine, 2'-deoxy-5-ethynyl- |
| CAS | 61135-33-9 |
| Foromo ea limolek'hule | C11H12N2O5 |
| Boima ba Molek'hule | 252.23 |
| Lintlha tsa polokelo | -20°C |
| Khoutu ea Lekhetho e Kopantsoeng | 29349990 |
Tlhaloso ea Sehlahisoa
| Ponahalo | E tšoeu ho ea ho Orange ho ea phofo e tala ho kristale |
| Tlhahlobo | ≥99% |
Phuputso ena e ile ea etsoa ho batlisisa phello ea ho ata ha li-peptide tsa soya tsa meroho ho lisele tsa batho ba baholo (ASCs) ha ho se na serum le mekhoa ea bona ea ts'ebetso.Ho ata ha lisele tsa 'mele tsa mesenchymal stem cell (ADSCs) le lisele tsa mesenchymal stem tse tsoang maling (CB-MSCs) tse tšoaroang ka soy peptide li fumanoe li eketseha haholo holima 3-(4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide le Click-iT 5-ethynyl-2'-deoxyuridine flow cytometry assay.Ntle le moo, li-peptide tsa soya li lebisitse ho phosphorylation ea p44/42 MAPK (ERK), sepheo sa mammalian sa rapamycin (mTOR), p70 S6 kinase, S6 ribosomal protein (S6RP) le eukaryotic initiation factor 4E (eIF4E) ho ADSCs.Ho feta moo, tlhahlobo ea bongata ba li-cytokine e senoletse hore tlhahiso ea phetoho ea kholo-beta1 (TGF-β1), vascular endothelial growth factor le interleukin-6 e ile ea eketseha haholo ka lebaka la phekolo ea soy peptide ka bobeli ADSCs le CB-MSCs.Ka mokhoa o ts'oanang, phosphorylation ea soy peptide-induced phosphorylation ea tsela ea ERK/mTOR/S6RP/eIF4E e ne e koetsoe ka lebaka la ho phekoloa pele le PD98059, e leng ERK inhibitor e khethehileng.Ho feta moo, ho thibela TGF-β1 ka PD98059 pele ho phekoloa le ho fokotseha ho latellanang ha ho ata ha ADSC ho senotse hore TGF-β1 e etsa hore phosphorylation ea mTOR/S6RP/eIF4E.Ka kakaretso, liphetho tsa phuputso ena li bontša hore tlhahiso ea TGF-β1 e itšetlehileng ka ERK e phetha karolo ea bohlokoa ho ata ho bakoang ke soya peptide ea ADSC tlas'a maemo a serum.Copyright © 2012 Elsevier Inc. Litokelo tsohle li sirelelitsoe.
