Guanosine-5'-diphosphate, letsoai la disodium Cas: 7415-69-2 phofo e tšoeu 98%
| Nomoro ea lethathamo | XD90756 |
| Lebitso la Sehlahiswa | Guanosine-5'-diphosphate, letsoai la disodium |
| CAS | 7415-69-2 |
| Foromo ea limolek'hule | Setšoantšo sa C10H13N5Na2O11P2 |
| Boima ba Molek'hule | 487.16 |
| Lintlha tsa polokelo | -15 ho ea ho -20 ° C |
| Khoutu ea Lekhetho e Kopantsoeng | 29349990 |
Tlhaloso ea Sehlahisoa
| Ponahalo | Phofo e tšoeu |
| Tlhahlobo | >99% |
| Metsi | <10% |
RasGrf1 le RasGrf2 ke lintlha tse fapanyetsanoang tsa mammalian guanine nucleotide tse khonang ho kenya tšebetsong Ras kapa Rho GTPases tse itseng.Liphatsa tsa lefutso tsa RasGrf li hlahisoa ka mokhoa o ikhethileng tsamaisong ea methapo e bohareng, leha polelo e ikhethileng ea locus e ka hlaha le libakeng tse ling.RasGrf1 ke mofuta oa bo-ntate, o hatisitsoeng ka mor'a tsoalo.Ka lehlakoreng le leng, RasGrf2 ha e hatisoe mme e bonts'a mokhoa o pharalletseng oa polelo.Mefuta e fapaneng ea li-isoform bakeng sa liphatsa tsa lefutso ka bobeli e boetse e bonoa maemong a fapaneng a liselefouno.Liprotheine tsa RasGrf li bonts'a libopeho tsa modular tse entsoeng ke libaka tse ngata tse kenyelletsang CDC25H le DHPH motifs tse ikarabellang bakeng sa ho khothaletsa phapanyetsano ea GDP/GTP, ka ho latellana, ho lipehelo tsa Ras kapa Rho GTPase.Likarolo tse fapaneng li bohlokoa ho hlalosa ts'ebetso ea bona ea mantlha ea phapanyetsano le ho hlophisa semelo sa ts'ebetso ea bona e le ho hokahanya mats'oao a fapaneng a holimo ho lipehelo tse fapaneng tse tlase le likarabelo tsa mehala.Ho sa tsotelehe homology ea bona, RasGrf1 le RasGrf2 li bonts'a lintlha tse fapaneng tsa sepheo le mesebetsi e sa amaneng ea ts'ebetso maemong a fapaneng a matšoao a amanang le kholo ea lisele le karohano hammoho le thabo ea neuronal le karabelo kapa polasetiki ea synaptic.Le hoja li-RasGrfs ka bobeli li ka sebelisoa ke li-receptor tsa glutamate, li-receptor tsa G-protein-coupled kapa liphetoho ho intracellular calcium concentration, ke RasGrf1 feela e tlalehoang e sebelisoa ke LPA, cAMP, kapa Trk e entsoeng ke agonist le li-cannabinoid receptors.Tlhahlobo ea mefuta e fapaneng ea litoeba tse kokotang e sibollotse tlatsetso e ikhethileng ea RasGrf1 ts'ebetsong ea mohopolo le ho ithuta, ho amohela lifoto, taolo ea kholo ea kamora ho pepa le boholo ba 'mele le ts'ebetso ea pancreatic β-cell le glucose homeostasis.Bakeng sa RasGrf2, likarolo tse ikhethileng ho ata ha lymphocyte, likarabelo tsa matšoao a T-cell le lymphomagenesis li hlalositsoe.
