Lihlahisoa

Li-analogue tse 'maloa tsa guanosine, ke hore, acyclovir (le prodrug ea eona ea molomo valaciclovir), penciclovir (ka sebopeho sa eona sa molomo, famciclovir) le ganciclovir, li sebelisoa haholo bakeng sa kalafo ea herpesvirus [ke hore, herpes simplex virus mofuta oa 1 (HSV-1), le mofuta. 2 (HSV-2), varicella-zoster virus (VZV) le/kapa human cytomegalovirus (HCMV)] mafu.Lilemong tsa morao tjena, ho entsoe li-analogue tse 'maloa tse ncha tsa guanosine, ho kenyelletsa le 3-membered cyclopropylmethyl le -methenyl derivatives (A-5021 le synguanol) le tse 6 tsa D- le L-cyclohexenyl derivatives.Ts'ebetso ea li-acyclic/carbocyclic guanosine analogues e khethiloe khahlano le mefuta e mengata ea livaerase, ho kenyeletsoa HSV-1, HSV-2, VZV, HCMV, le human herpesviruses mofuta 6 (HHV-6), mofuta oa 7 (HHV- 7) le mofuta oa 8 (HHV-8), le kokoana-hloko ea lefu la sebete la mofuta oa B (HBV).Li-analogues tse ncha tsa guanosine (ke hore, A-5021 le D- le L-cyclohexenyl G) li fumanoe li sebetsa haholo khahlanong le livaerase tseo (HSV-1, HSV-2, VZV) tse kenyelletsang thymidine kinase (TK), e fana ka maikutlo a hore hore mosebetsi oa bona oa antiviral (bonyane ka mokhoa o sa fellang) o itšetlehile ka phosphorylation ke TK e bakoang ke kokoana-hloko.Ts'ebetso e tšoailoeng ea antiviral e boetse e hlokometsoe ka A-5021 khahlano le HHV-6 le ka D- le L-cyclohexenyl G khahlano le HCMV le HBV.Ts'ebetso ea antiviral ea li-acyclic/carbocyclic nucleoside analogues e ka hlahisoa ka mokhoa o hlakileng ke mycophenolic acid, inhibitor e matla ea inosine 5'-monophosphate (IMP) dehydrogenase.Li-analogues tse ncha tsa carbocyclic guanosine (ke hore, A-5021 le D- le L-cyclohexenyl G) li na le ts'episo e kholo, eseng feela e le li-antiviral bakeng sa kalafo ea tšoaetso ea herpesvirus, empa hape le li-antitumor bakeng sa kalafo e kopaneng ea lefutso / chemotherapy ea mofets'e, hafeela (karolo ea) lisele tsa hlahala li fetisitsoe ke kokoana-hloko (HSV-1, VZV) TK gene.