Adenosine Cyclophosphate CAS: 60-92-4 99% phofo e tšoeu ea kristale
| Nomoro ea lethathamo | XD90570 |
| Lebitso la Sehlahiswa | Adenosine Cyclophosphate |
| CAS | 60-92-4 |
| Foromo ea limolek'hule | Setšoantšo sa C10H12N5O6P |
| Boima ba Molek'hule | 329.206 |
| Lintlha tsa polokelo | 2 ho isa ho 8 °C |
| Khoutu ea Lekhetho e Kopantsoeng | 29349990 |
Tlhaloso ea Sehlahisoa
| Ponahalo | Phofo e tšoeu ea kristale |
| Tlhahlobo | 99% |
Histamine H4 receptor (HRH4), e fumanoeng lilemong tse 13 feela tse fetileng, e nkuoa e le sepheo se ts'episang sa lithethefatsi bakeng sa allergy, ho ruruha, mafu a autoimmune le mofets'e, joalo ka ha ho bonahatsoa ke palo e ntseng e eketseha ea likhatiso tsa mahlale le likopo tsa patent.Leha boteng ba HRH4 bo bonahetse ka har'a testis, sebaka sa eona se ikhethileng kapa karolo ea eona ha e so thehoe.Mona, re ne re batla ho tseba ho kenya letsoho ha HRH4 taolong ea tšebetso ea lisele tsa Leydig.Re ile ra qala ho hlahloba polelo ea eona ho lisele tsa tumor tsa MA-10 Leydig eaba re hlahloba liphello tsa li-agonists tse peli tsa HRH4 ho steroidogenesis le ho ata.Re fumane hore HRH4 e hlahisoa ka mokhoa o sebetsang ka liseleng tsa MA-10, le hore ts'ebetso ea eona e lebisa ho thibelo ea tlhahiso ea cAMP ea LH/chorionic gonadotropin-induced cAMP le tlhahiso ea protheine ea Star.Ho feta moo, re bone ho fokotseha ha lisele tsa lisele ka mor'a phekolo ea agonist ea 24-h HRH4.Ka mor'a moo re ile ra fumana libaka tsa polelo ea HRH4 ho liteko tse tloaelehileng tsa rat, 'me ra fumana HRH4 immunostaining liseleng tsa Leydig tsa likhoto tse lilemo li 7-240, ha likhoto tsa matsatsi a 21 le tsona li hlahisitse polelo ea HRH4 ho li-gametes tsa banna.Qetellong, re ile ra lekola phello ea ts'ebetso ea HRH4 ho ata ha tloaeleho e tloaelehileng le rat Leydig cell culture, 'me ka bobeli li bontšitse hore li ka ba le phello e khahlanong le ho ata ha li-agonists tsa HRH4.Ka lebaka la bohlokoa ba histamine (2-(1H-imidazol-4-yl) ethanamine) ho motho (patho) physiology, boiteko bo tsoelang pele bo lebisitsoe ho hlakisang thepa e hlahang ea HRH4 le li-ligands tsa eona.Phuputso ena e senola libaka tse ncha tsa polelo ea HRH4, 'me e lokela ho nahanoa ka moralo oa li-agonists tse khethiloeng tsa HRH4 bakeng sa merero ea phekolo.
