Adenosine 5'-monophosphate disodium letsoai Cas: 4578-31-8
| Nomoro ea lethathamo | XD90587 |
| Lebitso la Sehlahiswa | Adenosine 5'-monophosphate disodium letsoai |
| CAS | 4578-31-8 |
| Foromo ea limolek'hule | Setšoantšo sa C10H12N5Na2O7P |
| Boima ba Molek'hule | 391.18 |
| Lintlha tsa polokelo | Ambient |
| Khoutu ea Lekhetho e Kopantsoeng | 29349990 |
Tlhaloso ea Sehlahisoa
| Ponahalo | Phofo e tšoeu kapa e sa koaeloang |
| Tlhahlobo | 99% |
| Litšepe tse boima | <10ppm |
| Mocheso oa polokelo | +20 ° C |
| Litaba tsa Metsi | <26.0% |
Ho beha leihlo pharmacodynamics ho kenyelletsa pharmacokinetics ke e 'ngoe ea maano a ho iketsetsa kalafo ea mycophenolate mofetil.Sepheo sa thuto ena e ne e le ho hlahisa mekhoa e hlokolosi ea metsi chromatography-tandem mass spectrometry (LC-MS/MS) bakeng sa tlhahlobo ea pharmacokinetics le pharmacodynamics ea mycophenolic acid (MPA).Likhakanyo tsa mycophenolic acid glucuronide (MPAG), mycophenolic acid acyl-glucuronide, hammoho le MPA le MPAG tse sa koaloang, li ile tsa khethoa, 'me mosebetsi oa inosine-5'-monophosphate dehydrogenase o ile oa baloa ka ho lekanya likhahla tsa xanthosine-5'-monophosphate e hlahisoang (XMP). ) le intracellular adenosine-5'-monophosphate ka mor'a ho kenngoa ha peripheral blood mononuclear cell (PBMC) lysates.Ho ile ha sebelisoa kholumo ea Mastro(TM) e se nang tšepe le lipaterone tse peli tsa gradient ho ntlafatsa moeli oa lipalo oa XMP ho isa ho 0.1 μM.Sehlopheng sa mahloriso sa MPA ea kliniki, ho hlaka ha lebelo la ho lekanya, ho nepahala ha letsatsi le har'a matsatsi le ho nepahala ho khotsofatsa tataiso ea US ea Tsamaiso ea Lijo le Lithethefatsi.The MPA concentrations in hematopoietic stem cell transplant (HSCT) bakuli ba khethiloeng ke tlhahlobo ea enzyme le mokhoa oa hona joale oa LC-MS / MS o bontšitse kamano e ntle (r (2) = 0.95, p <0.001).Thutong ena, re tlaleha mekhoa e hlokolosi le e tiisitsoeng ea LC-MS/MS ho lekola pharmacokinetics le pharmacodynamics ea MPA, e nang le kutloelo-bohloko ka ho lekaneng ho hlahloba palo e nyenyane ea li-lysate tsa PBMC tse bokelitsoeng nakoana ka mor'a HSCT.
