Lihlahisoa

Ho batlisisa phello ea oli ea spearmint liphetohong tse kang emphysema le polelo ea tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), matrix metalloproteinase-9 (MMP-9) le inhibitor ea lisele tsa metalloproteinase. -1 (TIMP-9) ka lipopolysaccharide (LPS) tse tšoaroang likhoto.Mohlala oa liphetoho oa Emphysematous o ile oa susumetsoa ke intracheal instillation ea LPS hang ka beke ho fihlela libeke tse 8 ho likhoto.Likhoto li ne li arotsoe ka taolo, dexamethasone (0.3 mg x kg(-1)), le oli ea spearmint (10, 30,100 mg x kg (-1)) lihlopha.Sehlopha se seng le se seng se ne se phekoloa ka saline, dexamethasone, le spearmint ea oli ka ho latellana bakeng sa libeke tse 4.Joale lipalo tse felletseng le tse fapaneng tsa lisele tse tšoeu tsa mali ho bronchoalveolar lavage fluid(BALF) li ile tsa etsoa.Liphetoho tsa pathologic tsa lisele tsa matšoafo tse kang sebopeho sa alveolar, ho ruruha ha moea, le goblet cell metaplasia li ile tsa bonoa ke HE le AB-PAS staining.Tlhaloso ea TNF-alpha, IL-1beta, TIMP-1 le MMP-9 e ne e lekantsoe. Ka bobeli spearmint le dexamethasone li fokolitse ho senyeha ha pulmonary alveolus.Kakaretso le tse fapaneng tsa lisele tse tšoeu tsa mali ho BALF ho kenyelletsa neutrophile le lymphocyte ea oli ea spearmint 100 mg x kg (-1) le sehlopha sa dexamethasone li fokotsehile haholo, 'me metaplasia ea sele ea goblet e ne e boetse e thibetsoe.Dexamethasone e bile le phello e thibelang polelo ea TNF-alpha, IL-1beta, TIMP-1 le MMP-9.Oli ea Spearmint 30, 100 mg x kg (-1) e fokolitse haholo TNF-alpha le IL-1beta ka ho latellana.Oli ea Spearmint 10, 30 le 100 mg x kg (-1) e ne e se na phello ho polelo ea TIMP-1, empa e ka fokotsa polelo ea MMP-9 haholo ka lisele tsa matšoafo. kaha e ntlafatsa tšenyo ea alveolar, ho ruruha ha matšoafo, le goblet cell metaplasia.Mochine ona o ka kenyelletsa ho fokotsa litaba tsa TNF-alpha, IL-1beta le ho thibela ho feteletsa ha matrix metalloproteinase-9 meleng ea matšoafo.