Fluorescein CAS: 2321-07-5 phofo e khubelu ea kristale ea Orange
| Nomoro ea lethathamo | XD90459 |
| Lebitso la Sehlahiswa | Fluorescein |
| CAS | 2321-07-5 |
| Foromo ea limolek'hule | C20H12O5 |
| Boima ba Molek'hule | 332.31 |
| Lintlha tsa polokelo | Ambient |
| Khoutu ea Lekhetho e Kopantsoeng | 32129000 |
Tlhaloso ea Sehlahisoa
| Ponahalo | Orange/ phofo e khubelu ea kristale |
| Tlhahlobo | 99% |
| Tahlehelo ka ho Omisa | 1% boholo |
Cerebral dopamine neurotrophic factor (CDNF) protheine e bontšitsoe ho sireletsa tsela ea nigrostriatal dopaminergic ha e fanoa e le intrastriatal infusions mefuteng ea likhoto le litoeba tsa lefu la Parkinson (PD).Thutong ena, re ile ra hlahloba phello ea neuroprotective ea CDNF e fanoeng ka recombinant adeno-associated viral (AAV) serotype 2 vector ka rat 6-hydroxydopamine (6-OHDA) ea mohlala oa PD.Li-vector tsa AAV2 tse kenyang CDNF, glial cell line-derived neurotrophic factor (GDNF), kapa protheine e tala ea fluorescent li ile tsa kenngoa ho rat striatum.Tlhahlobo ea polelo ea protheine e bonts'itse hore vector ea rona ea AAV2 e ile ea tlisa liphatsa tsa lefutso bokong 'me ea fana ka tlhahiso ea nako e telele ea liprotheine.Libeke tse peli ka mor'a ente ea vector ea AAV2, 6-OHDA e ile ea kenngoa ka har'a rat striatum, ea baka ho senyeha ho tsoelang pele ha nigrostriatal dopaminergic system.Kalafo e nang le AAV2-CDNF e entse hore ho be le phokotseho e hlakileng ea lipotoloho tsa ipsilateral tse bakiloeng ke amphetamine ha li ntse li fana ka tšireletso e sa fellang ea lisele tsa tyrosine hydroxylase (TH) -immunoreactive liseleng tsa rat substantia nigra pars compacta le likhoele tse sebetsang tsa TH ho striatum.Liphello tsa thuto ena li fana ka bopaki bo eketsehileng ba hore CDNF e ka nkoa e le phekolo e ka 'nang ea e-ba teng ea lefu la Parkinson.
