![3,3′,5,5′-Tetramethyl-[1,1'-biphenyl]-4,4′-diamine Cas:54827-17-7 99% Setšoantšo se Featured](http://cdn.globalso.com/xdbiochems/54827-17-71.jpg)
3,3′,5,5′-Tetramethyl-[1,1'-biphenyl]-4,4′-diamine Cas: 54827-17-7 99%
| Nomoro ea lethathamo | XD90518 |
| Lebitso la Sehlahiswa | 3,3',5,5'-Tetramethyl-[1,1'-biphenyl] -4,4'-diamine |
| CAS | 54827-17-7 |
| Foromo ea limolek'hule | C16H20N2 |
| Boima ba Molek'hule | 240.34 |
| Lintlha tsa polokelo | 2 ho isa ho 8 °C |
| Khoutu ea Lekhetho e Kopantsoeng | 29215990 |
Tlhaloso ea Sehlahisoa
| Ponahalo | Bosoeu, bosoeu ho isa ho bohlooho bo boputsoa kapa phofo e mosehla |
| Tlhahlobo | >99% |
| Tahlehelo ka ho Omisa | <2.0% |
| Bakeng sa tšebeliso ea lipatlisiso feela, eseng molemong oa batho | lipatlisiso li sebelisoa feela, eseng molemong oa batho |
Chefo ea Ricin (RT) ke chefo ea bobeli e bolaeang ka ho fetisisa e tsejoang;e khethiloe ke CDC e le moemeli ea khethiloeng.RT e entsoe ke semela sa linaoa tsa castor;ho hakanngoa hore lithane tse 50,000 tsa RT li hlahisoa selemo le selemo e le sehlahisoa sa oli ea castor.RT e na le li-subunits tse peli, ketane ea ribotoxic A (RTA) le ketane ea B e tlamang galactose (RTB).RT e tlama liseleng tsohle tsa mammalia 'me hang ha e kentsoe kahare, RTA e le' ngoe e etsa hore li-ribosome tsohle li se ke tsa sebetsa ka seleng.E tsamaisoa e le aerosol, RT e baka tšenyo e potlakileng ea matšoafo le fibrosis e lateloang ke lefu.Ha ho na liente tse amohetsoeng tsa Tsamaiso ea Lijo le Lithethefatsi 'me liphekolo li sebetsa lihoreng tse seng kae feela kamora ho pepeseha.Re entse ente e recombinant RTA e nang le liphetoho tse peli V76M/Y80A (RiVax).Protheine e hlahisoa ho Escherichia coli 'me ha e na chefo ebile ha e na immunogenic ho litoeba, mebutlanyana le batho.Ha litoeba tse entetsoeng li qholotsoa ka RT e kentsoeng, e nang le aerosolized, kapa ka molomo (gavaged) RT, li sirelelitsoe ka ho feletseng.Hona joale re thehile sebopeho se thermostable, aluminium-adjuvant-containing ea RiVax mme ra e leka ka rhesus macaques.Ka mor'a ho entoa ka makhetlo a mararo, liphoofolo li ile tsa hlahisa masole a 'mele a ileng a li sireletsa ka ho feletseng ho lethal dose la aerosolized RT.Lisireletsi tsena li ile tsa fokotsa RT 'me tsa qothisana lehlokoa le maemo a fapaneng ka phanele ea li-anti-monoclonal tsa mouse tse tsejoang ka ho lemoha li-epitopes ho RTA ea tlhaho.Boemo ba tlholisano ea li-antibody bo ka emelang lets'oao la ts'ireletso ea immunologic.Habohlokoa, tekeno e tšoanang e ile ea bonoa ho sebelisoa sera ho tsoa ho batho ba entetsoeng ke RiVax.
