Phosphatase, alkaline CAS:9001-78-9 tšoeu, bohlooho bo bosoeu kapa perekisi monoclinic kristale kapa phofo
| Nomoro ea lethathamo | XD90379 |
| Lebitso la Sehlahiswa | Phosphatase, alkaline |
| CAS | 9001-78-9 |
| Foromo ea limolek'hule | C21H36N8O6 |
| Boima ba Molek'hule | 496.57 |
| Lintlha tsa polokelo | 2 ho isa ho 8 °C |
| Khoutu ea Lekhetho e Kopantsoeng | 35079090 |
Tlhaloso ea Sehlahisoa
| Tlhahlobo | 99% |
| Ponahalo | kristale kapa phofo e tšoeu, e bohlooho kapa perekisi monoclinic |
Le hoja fluoride e tsejoa hore e susumetsa ho thehoa ha masapo, mekhoa ea motheo ha e utloisisoe ka botlalo.Liphuputso tsa morao-rao li kentse tsela ea Wnt/β-catenin e le mokhoa o moholo oa pontšo ho baeloji ea masapo.Lithuto tsa rona tsa pejana li bontšitse karolo e ka bang teng ea canonical Wnt pathway ho thehoeng ha masapo a likhoto tse sa foleng tse pepesitsoeng ke fluoride, empa mochine o ntse o sa hlaka.Phuputso ea morao-rao e ile ea etsa qeto ea ho kenya letsoho ha Wnt / β-catenin pontšo ea phapang ea osteoblastic e bakoang ke fluoride.Re sebelisa li-osteoblasts tse ka sehloohong tsa rat, re bontšitse hore fluoride e khothalelitse haholo ho ata ha li-osteoblasts le polelo ea alkaline phosphate (ALP) hammoho le boemo ba polelo ea mRNA ea matšoao a ho khetholla masapo, ho kenyelletsa mofuta oa I collagen (COL1A1), ALP le osteonectin.Re ile ra boela ra fumana phosphorylations e entsoeng ke fluoride ho serine 473 ea Akt le serine 9 ea glycogen synthase kinase-3β (GSK3β), e ileng ea fella ka thibelo ea GSK-3β 'me ka mor'a moo ho bokellana ha nyutlelie ea β-catenin, joalokaha ho bontšoa ke Western blot le immunofluoresce .Ho feta moo, fluoride e boetse e hlahisitse polelo ea mofuta oa Wnt-targeted gene runt-related transcription factor 2 (Runx2).Habohlokoa, phello e ntle ea fluoride mosebetsing oa ALP le lipolelo tsa mRNA tsa COL1A1, ALP, osteonection le Runx2 li ile tsa felisoa ke DKK-1, blocker ea Wnt/β-catenin receptor.Ha li kopane, liphuputso tsena li fana ka maikutlo a hore fluoride e khothalletsa phapang ea osteoblastic ka ts'ebetso e itšetlehileng ka Akt- le GSK-3β ea tsela ea pontšo ea Wnt / β-catenin ho li-osteoblasts tse ka sehloohong tsa rat.Liphuputso tsa rona li fana ka leseli le lecha mabapi le mekhoa ea ts'ebetso ea fluoride ho osteoblastogenesis.
