Lysostaphin CAS:9011-93-2 C10H14N2O3S
| Nomoro ea lethathamo | XD90384 |
| Lebitso la Sehlahiswa | Lysostaphin |
| CAS | 9011-93-2 |
| Foromo ea limolek'hule | Setšoantšo sa C10H14N2O3S |
| Boima ba Molek'hule | 242.29 |
Tlhaloso ea Sehlahisoa
| Tlhahlobo | 99% |
| Ponahalo | Phofo e tšoeu |
Bohloko ba ho hanyetsa likokoana-hloko hammoho le khaello ea li-antimicrobial tse ncha li ekelitse thahasello ho nts'etsopele ea li-antimicrobial peptides (AMPs) e le mekhoa e mecha ea phekolo.Phuputsong ena, re ile ra hlahloba mesebetsi ea antimicrobial ea li-peptide tse peli tse khutšoanyane tsa maiketsetso, e leng, RRIKA le RR.Li-peptide tsena li bonts'itse ts'ebetso e matla ea antimicrobial khahlano le Staphylococcus aureus, 'me litlamorao tsa tsona tsa antimicrobial li ile tsa matlafatsoa haholo ka ho eketsoa ha li-amino acid tse tharo ho C terminus, e leng se ileng sa eketsa amphipathicity, hydrophobicity, le tefiso ea marang-rang.Ho feta moo, RRIKA le RR li bontšitse phello e kholo le e potlakileng ea baktheria khahlano le Staphylococcus isolates ea bongaka le e hananang le lithethefatsi, ho kenyeletsoa Staphylococcus aureus (MRSA) e hanyetsanang le methicillin, vancomycin-intermediate S. aureus (VISA), S. aureus e hanyetsanang le vancomycin (VRSA) , S. aureus e hanyetsanang le linezolid, le Staphylococcus epidermidis e hanyetsanang le methicillin.Ho fapana le li-AMPs tse ngata tsa tlhaho, RRIKA le RR li ile tsa boloka mosebetsi oa majalefa boteng ba likarolo tsa 'mele tsa NaCl le MgCl2.Ka bobeli RRIKA le RR li matlafalitse polao ea lysostaphin ka makhetlo a fetang 1,000 le ho felisa libaka tse ikhethileng tsa MRSA le VRSA nakong ea metsotso e 20.Ho feta moo, li-peptide tse hlahisitsoeng li ne li phahametse ho fokotsa li-biofilms tse khomarelang tsa S. aureus le S. epidermidis ha li bapisoa le liphello tsa lithibela-mafu tse tloaelehileng.Liphuputso tsa rona li bonts'a hore litlamorao tsa staphylocidal tsa li-peptide tsa rona e bile ka ho kenella ha lera la baktheria, e leng se lebisang ho lutla ha litaba tsa cytoplasmic le lefu la lisele.Ho feta moo, li-peptide li ne li se chefo ho lisele tsa HeLa ho 4- ho 8-folds ea tsona ea antimicrobial concentrations.Mesebetsi e matla le e sa utloeleng letsoai ea likokoana-hloko tsa li-peptide tsena li hlahisa motho ea khahlehang oa phekolo bakeng sa phekolo ea mafu a mangata a S. aureus a hanyetsanang le lithethefatsi.
