Lihlahisoa

Li-receptor tsa ATP-gated P2X3 ke li-transducers tsa bohlokoa tsa li-nociceptive stimuli 'me li batla li hlahisoa ka ho khetheha ke li-neuron tsa ganglion tse utloahalang.Ho mouse trigeminal ganglion (TG), P2X3 receptor function e matlafatsoa ka mokhoa o sa lebelloang ke pharmacological block of natriuretic peptide receptor-A (NPR-A), e hlalosang karolo e ka 'nang ea e-ba e thibelang ea li-peptide tsa endogenous natriuretic ho nociception mediated by P2X3 receptors.Ho hloka phetoho ho polelo ea protheine ea P2X3 e bonts'a phetoho e rarahaneng eo mekhoa ea eona ea ho theola tšebetso ea li-receptor tsa P2X3 e ntse e sa hlake. thibela anantin.Kahoo, re ile ra etsa lipatlisiso ka liphetoho tsa kabo ea li-receptor tsa P2X3 ka har'a lipid raft membrane, boemo ba bona ba phosphorylation, hammoho le ts'ebetso ea bona ka patch clamping.Ho lieha ho qala ha P2X3 deensitization e ne e le mokhoa o mong oa ntlafatso e susumetsoang ke anantin ea ts'ebetso ea P2X3.Anant ts'ebetsong e bakile kabo bocha ea receptor ea P2X3 sebakeng sa lipid raft compartment le ho fokotsa P2X3 serine phosphorylation, liketsahalo tse peli tse neng li sa itšetlehe ka lintho tse ling.Inhibitor ea protheine kinase e itšetlehileng ka cGMP le siRNA-mediated knockdown ea BNP li etsisa phello ea anantin.Thibelo ea tonic ea ts'ebetso ea li-receptor tsa P2X3 ka litsela tsa BNP/NPR-A/PKG e etsahala ka mekhoa e 'meli e fapaneng: P2X3 serine phosphorylation le phetisetso ea li-receptor ho likarolo tsa membrane tse se nang raft.Mokhoa ona o mocha oa taolo ea li-receptor e ka 'na ea e-ba sepheo sa lithuto tsa nakong e tlang tse reretsoeng ho fokotsa ts'ebetso ea receptor ea P2X3 e sa laoleheng ka bohloko bo sa foleng.