Lihlahisoa

Neuroblastoma, kankere ea tsamaiso ea methapo e nang le kutloelo-bohloko, ke hlahala e atileng ka ho fetesisa ea extracranial ho bana.Ho holisa MYCN le ho eketseha ha matšoao a BDNF/TrkB ke likarolo tsa lihlahala tse kotsi haholo;leha ho le joalo, ke ˜25% feela ea lihlahala tse kotsi tse bontšang likarolo tsena.Kahoo, ho tsebahatsa li-biomarker tse eketsehileng le sepheo sa kalafo ho bohlokoa.Joalo ka aminoacylase 1 (ACY1), amino acid deacetylase, ke mohatelli oa hlahala ka har'a lisele tse nyane tsa matšoafo le renal cell carcinomas, re ile ra batlisisa hore na eona kapa litho tse ling tsa lelapa aspartoacylase (ASPA, aminoacylase 2) kapa aminoacylase 3 (ACY3) e ka sebetsa. mosebetsi o tšoanang ho neuroblastoma.Polelo ea Aminoacylase e ile ea hlahlojoa ho TrkB-positive, MYCN-amplified (SMS-KCNR le SK-N-BE) le TrkB-negative, non-MYCN-amplified (SK-N-AS, SK-N-SH, SH-SY5Y le SH-EP) mela ea lisele tsa neuroblastoma.Aminoacylase ka 'ngoe e ne e bonts'a sebaka se ikhethileng sa sebaka (ke hore, cytosolic ACY1, ASPA e amanang le membrane le nuclear ACY3).Ha lisele tsa SK-N-SH li ne li phekoloa ka li-neural differentiation agents (mohlala, retinoic acid le cAMP) mecheng ea litaba e nang le 10% serum, ACY1 e ne e le eona feela aminoacylase eo polelo ea eona e neng e laoloa.ASPA e hlalositsoe haholo-holo ka lisele tsa SH-EP tsa sublineage ea glial.ACY3 e hlahisitswe haholo meleng ya TrkB-positive, MYCN-amplified.Li-aminoacylase tse tharo kaofela li ile tsa hlahisoa ka tšoelesa ea adrenal e tloaelehileng ea motho, sebaka se tloaelehileng sa tlhaho ea neuroblastoma, empa ke ACY1 le ACY3 feela tse bonts'ang polelo e bonoang ho hlahala ea mantlha ea neuroblastoma.Tlhahisoleseding ea data ea Bioinformatics ea ho pholoha ha Kaplan-Meier e senotse hore polelo e phahameng ea ACY3 e amana le ho fosahala, athe polelo e tlase ea ACY1 kapa ASPA e amana le ho fosahala.Lintlha tsena li fana ka maikutlo a hore polelo ea aminoacylase e senyeha ho neuroblastoma