N,N'-Methylenebisacrylamide Cas: 110-26-9 98% Phofo e tšoeu
| Nomoro ea lethathamo | XD90231 |
| Lebitso la Sehlahiswa | N,N'-Methylenebisacrylamide |
| CAS | 110-26-9 |
| Foromo ea limolek'hule | C7H10N2O2 |
| Boima ba Molek'hule | 154.1665 |
| Lintlha tsa polokelo | 2 ho isa ho 8 °C |
| Khoutu ea Lekhetho e Kopantsoeng | 29241900 |
Tlhaloso ea Sehlahisoa
| Tlhahlobo | >98% |
| Metsi a sa qhibidihang | <0.5% |
| Ponahalo | Phofo e tšoeu |
| Li-sulfate tsa inorganic | <0.5% |
| Bakeng sa tšebeliso ea lipatlisiso feela, eseng molemong oa batho | lipatlisiso li sebelisoa feela, eseng molemong oa batho |
Karolo ea bohlokoa ea tumor-associated fibroblasts (TAF) tsoelo-peleng ea mofets'e e se e hlakile mofetšeng o seng o monyane oa lisele tsa matšoafo (NSCLC).Leha ho le joalo, liphekolo tse khahlano le TAF li na le moeli ka lebaka la ho hloka kutloisiso mekhoeng e ikhethileng ea subtype e thehiloeng ho bokella ha bona.Mona, mochine (ke hore, matrix rigidity) le li-mitogenic cues tse qhibilihang tse tsamaisang ho bokellana ha TAF ho tsoa ho mefuta e meholo ea NSCLC: adenocarcinoma (ADC) le squamous cell carcinoma (SCC) li ile tsa aroloa.Li-fibroblasts li ile tsa hlahisoa ka har'a substrata e etselitsoeng ho bonts'a boima bo tloaelehileng kapa bo kang ba tumor maemong a fapaneng a serum, mme lits'ebetso tsa bohlokoa tsa taolo li ile tsa hlakisoa.Taolong ea li-fibroblasts tse tsoang liseleng tse se nang kotsi, ho thatafala ha matrix feela ho ile ha eketsa pokello ea fibroblast, 'me phello ena ea mochini e ne e le matla kapa e bapisoa le ea kholo e qhibilihang ho fihlela ho 0.5% serum.Lintlha tse susumetsang tsa ho tiea ha matrix li ne li khannoa ke β1 integrin mechano-sensing ka FAK (pY397), 'me li ne li amahanngoa le ho phahama ha posttranscriptally ho β1 integrin expression.Potoloho ea morao-rao ea tsamaiso ea mechano e ile ea boela ea hlokomeloa ho TAFs empa ka mokhoa o ikhethileng, hobane li-SCC-TAF li ne li bontša FAK e phahameng (pY397), polelo ea β1, le ERK1/2 (pT202/Y204) ho feta ADC-TAFs.Ho feta moo, ho thatafala ha matrix ho entse hore ho be le pokello e kholoanyane ea TAF ho SCC-TAFs (> 50%) ha e bapisoa le ADC-TAFs (10% -20%).Ka lehlakoreng le leng, li-SCC-TAF li ne li senyehile haholo ka serum, athe li-ADC-TAF li ne li arabela ho khatello e phahameng ea serum feela.Liphuputso tsena li fana ka bopaki ba pele ba taolo e ikhethileng ea mofuta oa NSCLC-TAF.Ho feta moo, lintlha tsena li tšehetsa hore mekhoa ea phekolo e reretsoeng ho tsosolosa matšoafo a tloaelehileng le / kapa taolo ea mechano e itšetlehileng ka β1 e ka 'na ea sebetsa khahlanong le SCC-TAFs, athe ho thibela pontšo ea kholo ea stromal e ka' na ea sebetsa khahlanong le ADC-TAFs. ho bokellana ho sa tloaelehang ha li-fibroblasts tse tšehetsang tumor ka har'a mefuta e 'meli e meholo ea mofetše oa matšoafo, e tla thusa ho nts'etsopele ea liphekolo tsa motho ka mong khahlano le lisele tsena.
