5-Sulfosalicylic acid dihydrate Cas: 5965-83-3 kristale e tšoeu ho isa bosoeu
| Nomoro ea lethathamo | XD90230 |
| Lebitso la Sehlahiswa | 5-Sulfosalicylic acid dihydrate |
| CAS | 5965-83-3 |
| Foromo ea limolek'hule | C7H10O8S |
| Boima ba Molek'hule | 254.215 |
| Lintlha tsa polokelo | Ambient |
| Khoutu ea Lekhetho e Kopantsoeng | 29182900 |
Tlhaloso ea Sehlahisoa
| Sulfate | 5.5% boholo |
| Mongobo | 22% max |
| Ponahalo | Khalase e tšoeu ho isa bosoeu |
| Kakaretso ea asiti | 99 - 104% |
| Tlhahlobo | 99% |
Li-polycation li hlahlojoa e le lijari tsa ho fana ka li-nucleic acid tsa kalafo.Li-polycations ke tse tloaelehileng tsa pharmacological inert ka mosebetsi o le mong oa ho fana ka thepa ea kalafo.Phuputso ena e tlaleha ho kopanngoa ha "self-immolative polycation" (DSS-BEN) e thehiloeng ho sethethefatsi sa analogue sa polyamine N(1),N(11) -bisethylnorspermine (BENSpm).Polycation e ne e etselitsoe ho sebetsa ka bobeli joalo ka sejalo sa phano ea liphatsa tsa lefutso le prodrug e shebileng dysregulated polyamine metabolism ho mofetše.Re sebelisa motsoako oa NMR le HPLC, re tiisa hore "self-immolative polycation" e kena ho senyeha ha intracellular ho sethethefatsi sa motsoali BENSpm.BENSpm e lokollotsoeng e felisa maemo a cellular a spermidine le spermine mme e laola polyamine catabolic enzymes spermine/spermidine N(1) -acetyltransferase (SSAT) le spermine oxidase (SMO).Li-polycation tse entsoeng li etsa li-polyplexes tse nang le DNA le ho thusa phetiso e sebetsang hantle.Ho nka monyetla oa bokhoni ba BENSpm ho hlokomelisa lisele tsa mofets'e ho li-apoptos tse hlahisitsoeng ke TNFα ke, re bonts'a hore DSS-BEN e ntlafatsa ts'ebetso ea ho bolaea lisele tsa TNFα gene therapy.Liphuputso tse tlalehiloeng li tiisa DSS-BEN e le mokhoa oa ho fana ka mekhoa e 'meli e ka fanang ka mofuta oa phekolo le ho ntlafatsa sephetho sa phekolo ea lefutso ka lebaka la ho senyeha ha intracellular ea DSS-BEN ho ea ho BENSpm le liphello tse ntle tse latelang tsa BENSpm ho polyamine e senyehileng. metabolism ka kankere.
