N-(2-Acetamide)iminodiacetic acid Cas: 26239-55-4 99% phofo e tšoeu
| Nomoro ea lethathamo | XD90194 |
| Lebitso la Sehlahiswa | ADA (N-(-2-Acetamido)iminodiacetic acid) |
| CAS | 26239-55-4 |
| Foromo ea limolek'hule | C6H10N2O5 |
| Boima ba Molek'hule | 190.15 |
| Lintlha tsa polokelo | Ambient |
| Khoutu ea Lekhetho e Kopantsoeng | 29241900 |
Tlhaloso ea Sehlahisoa
| Fe | <5ppm |
| Pb | <5ppm |
| Tahlehelo ka ho Omisa | <0.5% |
| Molora o sulfated | <0.1% |
| Ponahalo | Phofo e tšoeu |
| Li-solvents tse ling | Ha ho letho |
| Nako ea ho Qhala (9g ho 91ml 1M NaOH, Magnetic Striring) | <1 mets |
| A300 ( 9% ho 1 M NaOH) | <0.08% |
| Palo ea lintlha tsa ho qetela E shebiloe mokhoeng oa titration | Tse peli feela |
| pH Range e hlalosang Titration Second Endpoint | 9.1 - 10.1 |
| Sollubility (9% ho 1M NaOH) | E hlakileng le e se nang 'mala |
| Letsatsi la tlhahiso | |
| Metsi KF | <1% |
| Assay (Titration) ka motheo o omisitsoeng | >99.0% |
| Infrared | E lumellana |
Nucleoside adenosine e sebetsa tsamaisong ea methapo le pelo ka A2A receptor (A2AR).Karabelo ea boemo ba oksijene liseleng, mahloriso a adenosine plasma a laoloa ka ho khetheha ka motsoako oa eona ke CD73 le ka ho senyeha ha eona ke adenosine deaminase (ADA).CD26 ea endopeptidase e ka holim'a sele e laola bongata ba li-peptide tsa vasoactive le antioxidant, ka hona e laola phepelo ea oksijene ho lisele le karabelo ea khatello ea oxidative.Le hoja ho fetisoa ho feteletseng ha adenosine, CD73, ADA, A2AR, le CD26 ho arabela hypoxia ho ngotsoe hantle, liphello tsa hyperoxic le hyperbaric maemo a likarolo tsena li lokeloa ke ho nahaneloa ka ho eketsehileng.Likhoto le mohala oa sele oa Chem-3 oa murine o hlalosang A2AR o ne o pepesehetse 0.21 bar O2, 0.79 bar N2 (maemo a lefatše; normoxia);1 bar O2 (hyperoxia);2 bar O2 (hyperbaric hyperoxia);0.21 bar O2, 1.79 bar N2 (hyperbaria).Adenosine plasma concentration, CD73, ADA, A2AR expression, le mosebetsi oa CD26 li ile tsa sebetsanoa le vivo, 'me tlhahiso ea cAMP e ne e lebisitsoe ka cellulo.Bakeng sa maemo a vivo, 1) hyperoxia e fokotsehile boemo ba plasma ea adenosine le ts'ebetso ea T cell surface CD26, athe e ile ea eketsa polelo ea CD73 le boemo ba ADA;2) hyperbaric hyperoxia e ne e atisa ho matlafatsa mokhoa ona;le 3) hyperbaria feela e ne e se na tšusumetso e kholo ho litekanyetso tsena.Bokong le ka cellulo, 1) hyperoxia e fokotsehile polelo ea A2AR;2) hyperbaric hyperoxia e ile ea matlafatsa mokhoa ona;le 3) hyperbaria feela e bontšitse phello e matla ka ho fetisisa.Re fumane mokhoa o ts'oanang mabapi le motsoako oa A2AR mRNA bokong le tlhahiso ea cAMP liseleng tsa Chem-3.Kahoo boemo bo phahameng ba oksijene bo ne bo atisa ho fokotsa tsela ea adenosinergic le mosebetsi oa CD26.Hyperbaria feela e ile ea ama feela polelo ea A2AR le tlhahiso ea cAMP.Re buisana ka hore na mekhoa e joalo e bakoang ke hyperoxygenation e ka fokotsa joang, ka vasoconstriction, phepelo ea oksijene ho lisele le tlhahiso ea mefuta ea oksijene e sebetsang.
