Doxycycline hyclate CAS: 24390-14-5 99% Yellow crystalline powder
| Nomoro ea lethathamo | XD90368 |
| Lebitso la Sehlahiswa | Doxycycline hyclate |
| CAS | 24390-14-5 |
| Foromo ea limolek'hule | C22H24N2O8·HCl·0.5C2H6O·0.5H2O |
| Boima ba Molek'hule | 512.94 |
| Lintlha tsa polokelo | 2 ho isa ho 8 °C |
| Khoutu ea Lekhetho e Kopantsoeng | 29413000 |
Tlhaloso ea Sehlahisoa
| Tšilafalo A | <2% |
| Ho se hloekeB | <2% |
| Ho potoloha ho itseng | -105 ho ea ho -120 |
| pH | 2-3 |
| Ho se hloeke C | <0.5% |
| Ho se hloekeD | <0.5% |
| Tahlehelo ka ho Omisa | 1.4-2.8% |
| Tlhahlobo | 99% |
| Masalla a ho Ignition | <0.4% |
| Monyetla | 300-335 |
| Tšilafalo efe kapa efe e 'ngoe | <0.5% |
| Ponahalo | Yellow crystalline phofo |
| Tšilafalo F | <0.5% |
| Ho se hloekeE | <0.5% |
| Joala ba Ethyl | 4.5 - 6% |
| Ho monya ditshila | <0.07% |
Ho thehoa ha biofilm ka ho thibela meno ho ka lebisa ho peri-implant mucositis le peri-implantitis e latelang.Maemo ana a phekoloa ka lithibela-mafu tse kang doxycycline (Doxy).Mona re sebelisitse mokhoa oa electrochemical oa polarization ea cathodic ho roala Doxy holim'a bokantle ba thepa ea meno.Sebaka se koahetsoeng ke Doxy se bontšitse ho phatloha ho hoholo ka letsoai le nang le phosphate-buffer nakong ea lihora tse 24 tsa pele.Leha ho le joalo, palo e kholo ea Doxy e ile ea lula holim'a bonyane libeke tse 2 haholo-holo ka sampuli ea 5 mA-3 h e nang le tekanyo e phahameng ea Doxy, e fana ka maikutlo a bobeli ba pele le nako e telele ea bacteriostatic ea sebaka se koahetsoeng.Khemistri e kaholimo e ile ea hlahlojoa ka x-ray photoelectron spectroscopy le ion mass spectrometry ea bobeli.Boemo ba leholimo bo ile ba hlahlobjoa ka ho hlahloba electron microscopy le blue-light profilometry.Nako e telele ea polarization ho tloha 1 h ho ea ho 5 h le matla a phahameng a hona joale ho tloha ho 1 ho isa ho 15 mA cm (-2) e hlahisitse palo e phahameng ea Doxy holim'a surfa ce.Bokaholimo bo ne bo koahetsoe ke lera la Doxy e ka tlase ho 100 nm ntle le liphetoho tse kholo holima boemo ba leholimo.Thepa ea antibacterial ea sebaka se koahetsoeng ke Doxy se ile sa hlahlojoa ke biofilm le litlhahlobo tsa kholo ea planktonic ho sebelisa Staphylococcus epidermidis.Mehlala e koahetsoeng ka Doxy e fokolitse ho bokellana ha biofilm le kholo ea planktonic moetlong oa moro, hape e thibela kholo ea baktheria lipoleiting tsa agar.Phello ea antibacteria e ne e le matla bakeng sa lisampole tsa 5 mA-3 h tse koahetsoeng ka tekanyo e phahameng ea Doxy ha e bapisoa le ea 1 mA-1 h.Ka hona, sebaka se koahetsoeng ka Doxy se na le monyetla oa ho thibela colonization ea baktheria ha e pepesehetse molomong oa molomo.Ho roala ha Doxy e ka ba mokhoa o sebetsang oa ho laola peri-implant mucositis le ho thibela tsoelo-pele ea eona ho peri-implantitis.
