Doxorubicin hydrochloride CAS: 25316-40-9 99% phofo ea Orange-red Crystalline
| Nomoro ea lethathamo | XD90367 |
| Lebitso la Sehlahiswa | Doxorubicin hydrochloride |
| CAS | 25316-40-9 |
| Foromo ea limolek'hule | C27H29NO11·HCl |
| Boima ba Molek'hule | 579.98 |
| Lintlha tsa polokelo | 2 ho isa ho 8 °C |
| Khoutu ea Lekhetho e Kopantsoeng | 29419000 |
Tlhaloso ea Sehlahisoa
| MetsiLitaba | ≤ 4.0% |
| pH | 4.0-5.5 |
| Solubility | E qhibiliha ka: metsi, methanol le isotonic NaCl(aq).Ho se kopane ha chloroform le metsoako e meng ea tlhaho. |
| Lintho Tse Amanang | Doxorubicinone: ≤0.5% / Danunorubicin: ≤0.5% |
| Tlhahlobo | 99% |
| Metsoako e setseng | Acetone le joala: ≤2.5% / Acetone: ≤0.5% / Methanol: ≤500ppm |
| Litšila Tse Ling | ≤ 0.5% |
| Litšila ka Kakaretso | ≤ 2.0% |
| Crystallinity | E lumellana le USP |
| Ponahalo | Phofo e khubelu ea Crystalline |
| Boitsebiso | HPLC |
Bakuli ba nang le P-glycoprotein le HER2/neu (HER2) receptor-expressing overexpressing kankere ea matsoele hangata ba na le liphello tse mpe tsa kliniki.Leha ho le joalo, ha ho na lisele tsa kankere ea matsoele tse fumanehang khoebong tse HER2/P-glycoprotein tse habeli, tse fokotsang lipatlisiso sebakeng sena. kankere ea lisele tsa kankere ka phetisetso e tsitsitseng ea ATP-binding cassette (ABC) subfamily B member 1 (ABCB1) gene e kenyelletsang P-glycoprotein.ABCB1 liphatsa tsa lefutso tsa liphatsa tsa lefutso li ne li phahame ka mor'a phetisetso, e leng se lebisitseng keketseho ea 40 ea P-glycoprotein. poleloana.Hoa thahasellisa hore phetisetso ea ABCB1 e boetse e lebisitse ho eketseha ho fokolang ha liphatsa tsa lefutso tsa HER2 le liprotheine.Phetoho ea ABCB1 e ile ea eketsa litekanyetso tsa polelo ea P-glycoprotein haholo.Mokhoa o sebelisitsoeng mona bakeng sa ho hlahisa sele ena ea sele e loketse ho kenngoa ka potlako, ho tsitsitseng ha P-glycoprotein-mediated drug resistance ha e bapisoa le mekhoa ea tr aditional.Teko ea in vitro cytotoxicity e fana ka maikutlo a hore mohala oa sele o na le khanyetso e fapaneng ho mefuta e mengata e fapaneng ea li-chemotherapeutic agents.
