Polymyxin B sulfate CAS: 1405-20-5 Phofo e tšoeu
| Nomoro ea lethathamo | XD90360 |
| Lebitso la Sehlahiswa | Polymyxin B sulfate |
| CAS | 1405-20-5 |
| Foromo ea limolek'hule | Setšoantšo sa C55H96N16O13 · 2H2SO4 |
| Boima ba Molek'hule | 1385.61 |
| Lintlha tsa polokelo | 2 ho isa ho 8 °C |
| Khoutu ea Lekhetho e Kopantsoeng | 29419000 |
Tlhaloso ea Sehlahisoa
| Qetello | E lumellana le USP35 |
| Litšepe tse boima | <20ppm |
| pH | 5-7 |
| Boitsebiso | Chromatography ea metsi: e lumellana |
| Tlhahlobo | 99% |
| Ponahalo | Phofo e tšoeu |
| Tahlehelo ka ho Omisa | <6% |
| Solubility | E qhibiliha ka bolokolohi metsing, e qhibiliha hanyane ka har'a Ethanol |
| Sulfate | 15.5% - 17.5% |
| Boholo ba Karolo | <30µm |
| Potoloho e khethehileng ea optical | -78° -90° |
| Phenylalanine | 9.0%-12.0% |
| Li-pyrogens | E finyella litlhoko |
| Molora o sulfated | <0.75% |
| Palo eohle ea aerobic e sebetsang | <100cfu/g |
| Matla | > 6500 IU/mg |
The ExPortal protein secretion organelle ho Streptococcus pyogenes ke anionic phospholipid-e nang le membrane microdomain e ntlafalitsoeng ho Sec translocons le postsecretion protein biogenesis factor.Polymyxin B e tlama le ho senya botšepehi ba ExPortal, e leng se bakang tlhahiso e fosahetseng ea chefo e 'maloa.Ho fumana temohisiso ka lintlha tse susumetsang mokhatlo oa ExPortal, ho ile ha etsoa skrine ea liphatsa tsa lefutso ho khetha bakeng sa liphetoho tse hanyetsanang le polymyxin B tse bontšang botšepehi bo ntlafetseng ba ExPortal.Phetoho e felletseng ea liphatsa tsa lefutso tse 25 tse hanyetsanang e senotsoe ho tloha ho phetoho e le 'ngoe ho isa ho tse' nè ho genome e 'ngoe le e 'ngoe e kopantsoeng haholo-holo ka har'a lihlopha tse 10 tsa lefutso.Kaho ea liphatsa tsa lefutso tse nang le ho hlakoloa kapa tse kentsoeng ka bomong li bonts'itse hore liphatsa tsa lefutso tse 7 li fana ka khanyetso le ho matlafatsa bots'epehi ba ExPortal ka tahlehelo ea ts'ebetso, athe 3 e kanna ea ba ka lebaka la ts'ebetso le / kapa litlamorao tse kopaneng.Liphatsa tsa lefutso tsa mantlha tsa ho hanyetsa li kenyelletsa regulator ea transcriptal ea lipid biosynthesis, liphatsa tsa lefutso tse 'maloa tse amehang ho fumaneng limatlafatsi, le mefuta e fapaneng ea liphatsa tsa lefutso tse amehang likarabong tsa khatello ea maikutlo.Litho tse peli tsa sehlopha sa ho qetela le tsona li sebetsa e le balaoli ba libuka tsa SpeB cysteine protease e patiloeng.Tlhahlobo ea phetoho e atisang ho aroloa ka ho fetisisa, ho tlosoa ha nucleotide e le 'ngoe tseleng ea 9 e latellanang masala a adenine ho pstS, e kenyelletsang karolo ea sepalangoang se phahameng sa Pi transporter, e fana ka maikutlo a hore tatellano ena e sebetsa e le phetoho ea limolek'hule ho thusa ho ikamahanya le khatello ea kelello.Ka kopanelo, lintlha tsena li fana ka maikutlo a boteng ba karabelo ea "membrane stress" e khothalletsang botšepehi bo matlafalitsoeng ba ExPortal le ho hanyetsa li-peptide tsa cationic antimicrobial.
