DAPI (4,6-Diamidino-2-phenylindole dihydrochloride) CAS: 28718-90-3 99% Yellow powder
| Nomoro ea lethathamo | XD90505 |
| Lebitso la Sehlahiswa | DAPI (4,6-Diamidino-2-phenylindole dihydrochloride) |
| CAS | 28718-90-3 |
| Foromo ea limolek'hule | Setšoantšo sa C16H15N5 · 2HCl |
| Boima ba Molek'hule | 350.25 |
| Lintlha tsa polokelo | Ambient |
| Khoutu ea Lekhetho e Kopantsoeng | 2933998090 |
Tlhaloso ea Sehlahisoa
| Ponahalo | Phofo e mosehla |
| Tlhahlobo | 99% mets |
| Bakeng sa tšebeliso ea lipatlisiso feela, eseng molemong oa batho | Lipatlisiso li sebelisoa feela, eseng molemong oa batho |
Melatonin e kenya letsoho mesebetsing e mengata ea 'mele,' me e na le litlamorao tse fapaneng ho apoptosis liseleng tse tloaelehileng le tsa mofetše.Leha ho le joalo, mokhoa oa likarolo tsa eona tsa antitumor ha o utloisisoe hantle.Thutong ena, re bontša hore melatonin e ntlafatsa apoptosis e bakoang ke tunicamycin ka har'a lisele tsa kankere ea matsoele ea MDA-MB-231.Melatonin e laola pro-apoptotic protheine Bim expression maemong a transcriptional boteng ba tunicamycin.Melatonin e thibela polelo ea COX-2 e entsoeng ka tunicamycin ho MDA-MB-231 liseleng.Ho feta moo, ho thibela tšebetso ea COX-2 ho sebelisa COX-2 inhibitor, NS398, ho eketsa apoptosis e bakoang ke tunicamycin.Ho khahlisang, litlamorao tsena li ne li sa amahanngoa le litsela tsa matšoao a melatonin receptor.Pertussis chefo (e akaretsang Gi protein inhibitor) kapa luzindole (mohanyetsi ea sa tobang oa melatonin receptor) ha ea ka ea fetola phello ea melatonin.Ho phaella moo, melatonin e thibetse ts'ebetso ea NF-κB e entsoeng ke tunicamycin, translocation ea nyutlelie ea p65, le p38 MAPK act ivation.Thibelo ea Melatonin-mediated p38 MAPK e kentse letsoho ho fokotseng botsitso ba COX-2 mRNA.Ha re kopane, liphetho tsa rona li fana ka maikutlo a hore melatonin e ntlafatsa ts'ebetso ea antitumor ka ho laola maikutlo a Bim le ho theola-taolo ea polelo ea COX-2 liseleng tsa MDA-MB-231 tse nang le tunicamycin.
