Iodonitrotetrazolium chloride CAS: 146-68-9
| Nomoro ea lethathamo | XD90473 |
| Lebitso la Sehlahiswa | Iodonitrotetrazolium chloride |
| CAS | 146-68-9 |
| Foromo ea limolek'hule | Setšoantšo sa C19H13ClIN5O2 |
| Boima ba Molek'hule | 505.70 |
| Lintlha tsa polokelo | 2 ho isa ho 8 °C |
| Khoutu ea Lekhetho e Kopantsoeng | 32129000 |
Tlhaloso ea Sehlahisoa
| Boitsebiso | H-NMR |
| Ponahalo | Bosehla bo bobebe ho isa ho phofo ea lamunu |
| Tlhahlobo | >99% |
| Solubility | Tharollo e hlakileng |
Interferon-induced transmembrane protein 1 (IFITM1) ke e 'ngoe ea litho tsa malapa a protheine ea transmembrane e entsoeng ke interferon.Phuputsong ena, re tlalehile hore polelo e phahameng ea IFITM1 ka kankere ea colorectal ea motho (CRC) e amana haholo le CRC lymph node le metastasis ea sebaka se selelele hammoho le sethaleng se tsoetseng pele sa kliniki.Habohlokoa, polelo e phahameng ea IFITM1 ke ntlha e ikemetseng ea ho phela hantle.E le ho batlisisa mekhoa ea limolek'hule, re bontšitse hore ho fetella ha IFITM1 ka lisele tsa CRC ho khothalelitsoe, athe ho kokota ha polelo ea IFITM1 e thibetsoe, ho falla ha lisele / ho hlasela le tumorigenicity in vitro.Ho feta moo, re khethile Caveolin-1 (CAV1) e le sepheo se ka tlaase sa IFITM1-induced cell invasion, e le ho kokota ha CAV1 e hlakotsoeng ea siIFITM1 e thibelang ho hlaseloa ha lisele liseleng tsa CRC.Ho phaella moo, ho sehlopha sa CRC sa bakuli ba 229, polelo ea IFITM1 e amana ka tsela e fapaneng le polelo ea CAV1.Liphetho tsena li khothalelitse hore IFITM1 e khothaletse ho hlonepha ha lisele tsa CRC, 'me ke lets'oao le ka bang teng le sepheo sa kalafo bakeng sa CRC.
