Lihlahisoa

E le ho hlakisa ts'ebetso ea pele ea mineralization ea dentin, phello ea inhibitory ea 1-hydroxyethylidene-1,1-bisphosphonate (HEBP) ka mineralization ea denti e ile ea batlisisoa.Likhoto (100 g) li ne li kenngoa ka tlas'a letlalo ka HEBP (8 mg P / kg) bakeng sa 7 kapa 14 d, 'me li-incisors li ne li sebetsoa bakeng sa Ca histochemistry le / kapa electron microscopy.Li-incisors tse entsoeng ka HEBP li bonts'itse mela e meng e kang lere ea li-dentin tse nang le liminerale le tse se nang mineral qetellong ea apical.GBHA e senotse karabelo e leka-lekaneng ea Ca ka har'a matrix ea dentine e se nang mineralized moo electron microscopy e senotseng kabo e ruileng ea thepa e ntle e kang mesh e teteaneng ea elektronike.Matrix ea dentin ea mantle e sa hlahisoang ka liminerale e ne e le mpe bakeng sa Ca empa e ne e e-na le li-matrix vesicles (MVs) tse tletseng kristale le/kapa li-amorphous mineral deposits.Merafo ea dentine ea circumpulpal e etsahetse ntle le lesela la dentin ea mantle ea MV mefuteng e amehileng.Lintlha tsa rona li fana ka bopaki ba histochemical ba thepa e ka khonehang ea Ca-binding ea circumpulpal dentin matrix le ho ba sieo ha eona ka mantle dentin moo mineralization ea MV e hlahang teng.Ho dentin ea mantle, HEBP ha e kena-kenane le khōlo ea kristale ho MVs empa e thibela ho hlaha ha eona ka mor'a ho phatloha ha lera.Ho sisinyeha hore circumpulpal dentin matrix e na le monyetla oa ho etsa liminerale ntle le MV-mediated mineralization ea mantle dentin, le hoja li-MV li fumana sebaka sa pele le nako ea ho etsa liminerale tsa dentin.