Lihlahisoa

Activated thrombin-activatable fibrinolysis inhibitor (TAFIa) ke carboxypeptidase e nang le zinki mme e thibela haholo fibrinolysis.Ka hona, li-inhibitors tsa TAFIa li lebelletsoe ho sebetsa joalo ka li-profibrinolytic agents.Haufinyane tjena re tlalehile moralo le motsoako oa selenium-containing inhibitors ea TAFIa le ts'ebetso ea bona ea ho thibela.Mona re tlaleha meaho ea kristale ea selenium e matla, sebabole, le phosphinic acid-containing inhibitors e tlameletsoeng ho porcine pancreatic carboxypeptidase B (ppCPB).ppCPB ke TAFIa homologue 'me ke TAFIa e ikemetseng bakeng sa tlhahlobo ea crystallographic.Mehaho ea Crystal ea ppCPB e kopantsoeng le selenium compound 1a, analogue 2 ea sulfur, le phosphinic acid derivative EF6265 e ile ea khethoa ho 1.70, 2.15, le 1.90 Å resolution, ka ho latellana.Inhibitor e 'ngoe le e' ngoe e tlama sebakeng se sebetsang sa ppCPB ka mokhoa o ts'oanang le o hlokometsoeng bakeng sa li-inhibitors tse tlalehiloeng pele.Kahoo, ka li-complexes, selenium, sebabole, le phosphinic acid oksijene e hokahanya le zinki ho ppCPB.Ena ke tlhokomeliso ea pele le tlaleho ea selenium e hokahanyang le zinki ho CPB.