Cas e tala e potlakileng: 2353-45-9 E khubelu ho ea phofo e sootho
| Nomoro ea lethathamo | XD90527 |
| Lebitso la Sehlahiswa | Botala bo potlakileng |
| CAS | 2353-45-9 |
| Foromo ea limolek'hule | C37H34N2Na2O10S3 |
| Boima ba Molek'hule | 808.85 |
| Lintlha tsa polokelo | Ambient |
| Khoutu ea Lekhetho e Kopantsoeng | 32129000 |
Tlhaloso ea Sehlahisoa
| Ponahalo | E khubelu ho ea ho phofo e sootho |
| Tlhahlobo | ≥99% |
| Ntho e sa keneng ka metsi | ≤0.20% |
Ho ruruha ho sa foleng le ho lokisoa ha tsela ea moea, ho kenyelletsa le fibrosis, ho 'nile ha etsoa tlhahiso ea hore e be karolo ea bohlokoa ho pathophysiology ea asthma.Lithuto tse fetileng tsa airway fibrosis li 'nile tsa etsoa haholo-holo ka asthmatics e bonolo le e itekanetseng boemong ba "membrane e ka tlaase" (SBM) ea subepithelial.Boithuto ba hajoale bo ne bo etselitsoe ho lekola botenya bo boholo ba SBM ea moea le submucosal collagen deposition, joalo ka ha e lekantsoe ka mekhoa e meraro e fapaneng ea litšila ea collagen, ho li-endobronchial biopsies ho tloha ho 17 e matla, e itekanetseng e robong, le e supileng e bonolo ea asthmatics, hammoho le lithuto tse robeli tse tloaelehileng tsa taolo.Li-eosinophils tsa lisele le phetoho ea kholo-beta (TGF-beta) immunoreactivity le tsona li ile tsa hlahlojoa.Ho ne ho se na liphapang tse kholo ka har'a botenya ba SBM, submucosal collagen deposition, linomoro tsa eosinophil, kapa lisele tse ntle tsa TGF-beta har'a lihlopha tse tharo tsa asthmatics le lihlooho tse tloaelehileng tsa taolo.E bile feela ha ho hlahlojoa asthmatics eohle (n = 33) hammoho, moo SBM e teteaneng ka mokhoa o itekanetseng (p = 0.04), joalo ka ha e hlahlojoa ke collagen mofuta oa III immunostaining, e ileng ea bonoa ha e bapisoa le lithuto tse tloaelehileng tsa taolo.Ho sa tsotellehe phapang ena, ha ho na phapang e khōlō e ileng ea fumanoa ka palo ea submucosal collagen deposition le palo ea eosinophils kapa TGF-beta e hlalosang lisele ha ho bapisoa asthmatics eohle le lihlooho tse tloaelehileng tsa taolo.Ho phaella moo, ha ho na likamano tsa bohlokoa tse fumanoeng pakeng tsa collagen deposition le eosinophil count, TGF-beta expression level, FEV1, kapa nako ea asthma.Liphetho tsena li fana ka maikutlo a hore le hoja ho eketseha ha collagen deposition ho SBM boemong bo boholo ba moea ke tšobotsi ea asthma, e ka 'na ea se ke ea hlalosa phapang ea ho teba ha asthma.
