Biosynthesis ea proteoglycans le glycosaminoglycans boteng ba p-nitrophenyl-xyloside e ile ea ithutoa ho sebelisoa sistimi ea mantlha ea mae a mae a khoto a granulosa.Keketso ea p-nitrophenyl-xyloside sebakeng sa setso sa sele e bakile keketseho ea 700% ea [35S]sulfate incorporation (ED50 at 0.03 mM) ho li-macromolecules, tse neng li kenyelletsa liketane tsa mahala tsa chondroitin sulfate tse qalileng ho xyloside le proteoglycans ea matsoalloa.Liketane tsa mahala tsa chondroitin sulfate tse qalileng ho xyloside li ne li batla li kenngoa ka mokhoa o ikhethileng.Boholo ba limolek'hule tsa liketane tsa chondroitin sulfate bo fokotsehile ho tloha ho 40,000 ho ea ho 21,000 ha kakaretso ea [35S] sulfate e kenyelletsoa e ntse e ntlafatsoa, ho fana ka maikutlo a hore motsoako o ntlafetseng oa chondroitin sulfate o ile oa ferekanya mokhoa o tloaelehileng oa ho felisoa ha ketane ea glycosaminoglycan.Biosynthesis ea heparan sulfate proteoglycans e fokotsehile ka hoo e ka bang 50%, mohlomong ka lebaka la tlhōlisano boemong ba li-precursor tsa UDP-tsoekere.[35S]Sulfate incorporation e ile ea koaloa ka ho eketsoa ha cycloheximide ka nako ea halofo ea pele ea hoo e ka bang 2 hr ka boteng ba xyloside, athe ha xyloside e le sieo e ne e ka ba metsotso e 20.Phapano e kanna ea bonts'a sekhahla sa phetoho ea bokhoni ba ho kopanya glycosaminoglycan ka kakaretso.Sekhahla sa phetoho ea matla a motsoako oa glycosaminoglycan se bonoang liseleng tsa granulosa ea mahe a bomme se ne se le khuts'oane haholo ho feta se bonoang ho li-chondrocyte, se bonts'a taolo e lekanyelitsoeng ea ts'ebetso ea proteoglycan biosynthetic ts'ebetsong eohle ea metabolism ea lisele.
