Likhoto li ne li tsamaisoa ka tekanyo e le 'ngoe ea limela tsa tlhaho phenolic antioxidant Quercetin (QC) ka bolokolohi, liposome encapsulated le galactosylated liposome encapsulated mefuta 2 h pele ho tekanyo ea hepatotoxic ea carbontetrachloride (CCl4, 40% v / v ka oli ea mohloaare, 1 ml / kg b .wt).Har'a mefuta e meraro e fapaneng ea QC e lekiloeng, ke galactosylated liposomal QC feela e faneng ka tšireletso e kholo khahlanong le CCl4 e bakileng tšenyo ea hepatic oxidative.Ka mor'a lihora tse 24 tsa ente (SC) lisele tsa sebete tsa likhoto li ile tsa fumanoa li le kotsing ea ho senyeha ha oxidative e bakoang ke CCl4 'me e ne e hlahlojoa ke palo e eketsehileng ea conjugated diene ka lera la sebete.Keketseho ea makhetlo a mabeli ea conjugated diene ka ho kenngoa ha CCl4 e fokotsehile ho fihlela boemong bo tloaelehileng ka galactosylated liposomal QC pele ho phekolo.Carbontetrachloride e bakile tšenyo ea membrane liseleng tsa sebete mme e ile ea ahloloa ke tlhahlobo ea histopathological ea serum ea mali le lisele tsa sebete.Tšenyo ea 'mele ka ho kenngoa ha CCl4 e ile ea tsoela pele ho hlahlojoa ke boemo bo fokotsehileng ba enzyme ea Na+/K+ ATPase e fokotsehileng,' me e ile ea eketseha feela ka phekolo ea pele ea galactosylated liposomal QC.Carbontetrachloride e ile ea etsa hore ho fokotsehe ho hoholo ka bobeli ho li-antioxidant tsa li-enzymatic le molecular endogenous liseleng tsa sebete. Ho tepella maikutlong tsamaisong ea antioxidant liseleng tsa sebete ho ile ha thibeloa ka ho feletseng ka tekanyo e le 'ngoe ea galactosylated lipsosomal QC pele ho phekolo ea CCl4.Ho kenngoa ha sebete sa QC ho ile ha hakanngoa ka mor'a 2 h ea ente ea flavonoid (8.9 micromol / kg boima ba 'mele) (liforomo tsa mahala kapa tsa liposomal) le 85% ea QC e entsoeng e fumanoe sebete tabeng ea galactosylated liposomal QC.Le hoja ke 25% feela ea tekanyo e entsoeng ka sebete e ileng ea fumanoa sebeteng ha palo e tšoanang ea mahala ea QC e kenngoa.Carbontetrachloride e boetse e entse hore ho be le phetoho ho membrane fluidity mme e ile ea hlahlojoa ka ho fokotseha ha membrane micro-viscosity.Phekolo ea mahala ea QC e ile ea fella ka hore ho se ke ha e-ba le tšireletso khahlanong le keketseho e bakoang ke CCl4 ea hepatic membrane fluidity, athe galactosylated liposomal QC e ile ea fana ka tšireletso e kholo khahlanong le keketseho.Liphello tsa thuto ena li senoletse hore QC ka galactosylated liposome e ka fana ka tšireletso e kholo khahlanong le kotsi ea CCl4 e bakoang ke hepatocellular.
