Lihlahisoa

3,4,5-Trifluorophenylboronic acid ke motsoako oa lik'hemik'hale o nang le mekhoa e sa tšoaneng ea ho sebelisa lihlahisoa tsa tlhaho le lipatlisiso tsa meriana.E 'ngoe ea lisebelisoa tse ka sehloohong tsa 3,4,5-Trifluorophenylboronic acid e le setsi sa mohaho oa boronic nakong ea phetoho ea tšepe-catalyzed cross. -ho kopanya maikutlo.E ka itšoara ka li-electrophile tse fapa-fapaneng, tse kang aryl kapa vinyl halides, tlas'a tšusumetso ea palladium catalyst, ho etsa li-bond tsa carbon-carbon kapa carbon-heteroatom.Sena se nolofalletsa ho etsoa ha limolek'hule tse rarahaneng, ho kopanyelletsa le meriana, lik'hemik'hale tsa temo le metsoako e meng ea bohlokoa.Karolo ea trifluorophenyl ka har'a motsoako e ntlafatsa ts'ebetso ea eona 'me e ka susumetsa khetho ea karabelo, e etsa hore e be sesebelisoa se molemo ho organic synthesis. .Sehlopha sa trifluorophenyl se ka fetola litšebelisano tsa motsoako le lipakane tsa likokoana-hloko, tse kang li-enzyme kapa li-receptors, tse lebisang ho feto-fetoha ha thepa ea meriana.E ka ntlafatsa potency, selectivity, kapa botsitso ba metabolism ea motsoako, e leng se etsang hore e be mohaho o motle bakeng sa nts'etsopele ea lithethefatsi.Ho phaella moo, boronic acid moiety e teng ka 3,4,5-Trifluorophenylboronic acid e ka theha maqhama a reversible covalent le li-enzyme tse itseng, a fana ka menyetla ea ho qaptjoa ha li-enzyme inhibitors. .E ka sebelisoa ha ho etsoa thepa e tsoetseng pele, ho kenyeletsoa li-polymers kapa li-metal-organic frameworks, ho hlahisa thepa e lakatsehang.Ho ba teng ha sehlopha sa trifluorophenyl ho ka susumetsa ho qhibiliha ha thepa, botsitso ba mocheso, kapa thepa ea elektronike, ho etsa hore e tšoanelehe bakeng sa lisebelisoa tse sa tšoaneng, tse kang sensing, catalysis, kapa lisebelisoa tsa optoelectronic. e kopantsoe le ts'ebeliso ea bohlokoa ho organic synthesis, k'hemistri ea bongaka le mahlale a thepa.Ho kenya letsoho ha eona phetohong ea li-transition-catalyzed cross-coupling reactions e lumella ho hahoa ha limolek'hule tse rarahaneng, 'me karolo ea eona ea trifluorophenyl e ntlafatsa ts'ebetso le khetho ea eona.Ho k'hemistri ea bongaka, e ka sebelisoa ho nts'etsapele batho ba ka bang teng ho sebelisa lithethefatsi ka ho fetola litšebelisano le sepheo sa baeloji.Ho feta moo, ho kenyelletsoa ha eona ka har'a lisebelisoa tse tsoetseng pele ho nolofalletsa moralo oa thepa e nang le thepa e hlophisitsoeng.