Lihlahisoa

4-Chloro-2-fluoro-3-methoxyphenylboronic acid ke motsoako oa lik'hemik'hale o nang le lisebelisoa tse sa tšoaneng ho organic synthesis, chemistry ea meriana, le lisebelisoa tsa saense. phetohong ya tshepe-catalyzed cross-coupling reactions.E sebetsa e le mohaho oa mohaho oa boronic acid, o lumellang ho thehoa ha carbon-carbon kapa carbon-heteroatom bonds.Mohlala, motsoako ona o ka sebelisoa ho Suzuki-Miyaura cross-coupling reactions, moo e sebetsanang le aryl kapa vinyl halides tlasa palladium catalysis ho hlahisa metsoako ea biaryl.Liphetoho tsena tsa ho kopanya li-cross coupling li sebelisoa haholo ha ho etsoa limolek'hule tse rarahaneng tsa limolek'hule, ho kopanyelletsa le meriana le lik'hemik'hale tsa agrochemicals, hammoho le kaho ea lihlahisoa tsa tlhaho.Motsoako o ikhethang oa lihlopha tsa chlorine, fluorine, le methoxy ka sebopeho sa 4-Chloro-2 -fluoro-3-methoxyphenylboronic acid e thusa ho kopanya lihlahisoa tse fapaneng tse nang le thepa e hlophisitsoeng.Athomo ea chlorine e ka sebetsa e le sehlopha se tsamaisang mekhoa ea phetoho ea tšepe-catalyzed, e lebisang karabelo ka mokhoa o ikhethileng libakeng tse itseng ka har'a molek'hule.Fluorine substitution e fana ka lipophilicity e ntlafetseng, e ka susumetsang thepa ea pharmacokinetic ea motsoako le ho ntlafatsa bioavailability ea eona.Sehlopha sa methoxy, ka lehlakoreng le leng, se ka sebetsa e le sehlopha se sireletsang kapa sa kenya letsoho liphetohong tse sa tšoaneng tsa lik'hemik'hale.Ka k'hemistri ea meriana, 4-Chloro-2-fluoro-3-methoxyphenylboronic acid le lihlahisoa tsa eona li na le thahasello e le batho ba ka khonang ho sebelisa lithethefatsi.Lihlopha tse sebetsang tse kang chlorine le fluorine li ka fetola litšebelisano tsa motsoako le lipakane tsa likokoana-hloko le ho ntlafatsa thepa ea eona ea meriana.Ho feta moo, sehlopha sa methoxy se ka ntlafatsa botsitso ba metabolic 'me sa kenya letsoho ho lipophilicity le ho qhibiliha ha sona.Lintho tsena li etsa hore 4-Chloro-2-fluoro-3-methoxyphenylboronic acid e be sebaka sa bohlokoa sa ho qala ho hlahisa mekhoa e mecha ea phekolo masimong a kang oncology, mafu a tšoaetsanoang le ho ruruha. -3-methoxyphenylboronic acid e ka etsa hore ho thehoe li-ester tse tsitsitseng tsa boronate, tse 'nileng tsa sebelisoa ha ho etsoa thepa e nang le thepa e ikhethang.Lisebelisoa tsena li ka bonts'a thepa ea optical, elektroniki, kapa catalytic, ho latela sebopeho le sebopeho sa tsona.Ho kenyelletsoa ha 4-Chloro-2-fluoro-3-methoxyphenylboronic acid kapa lihlahisoa tsa eona ho lisebelisoa tsena ho ka fana ka ts'ebetso e khethehileng le ho ntlafatsa ts'ebetso ea bona. ka lebaka la k'hemistri ea eona e fapaneng le bokhoni ba ho theha limolek'hule tse sebetsang le lisebelisoa.Karolo ea eona ho liphetoho tse amanang le tšepe, e kopantsoeng le litšobotsi tse ikhethang tsa lihlopha tsa eona tse sebetsang, e etsa hore e be sesebelisoa sa bohlokoa ho organic synthesis le chemistry ea meriana.Ho feta moo, karolo ea boronic acid e thusa ho theha li-ester tsa boronate, tse tlatsetsang ho nts'etsopele ea lisebelisoa tse tsoetseng pele tse nang le thepa e hlophisitsoeng.