Tazobactam Cas: 89786-04-9
| Nomoro ea lethathamo | XD92373 |
| Lebitso la Sehlahiswa | Tazobactam |
| CAS | 89786-04-9 |
| Foromo ea molek'hulela | Setšoantšo sa C10H12N4O5S |
| Boima ba Molek'hule | 300.29 |
| Lintlha tsa polokelo | -15 ho ea ho -20 ° C |
| Khoutu ea Lekhetho e Kopantsoeng | 29419000 |
Tlhaloso ea Sehlahisoa
| Ponahalo | Phofo e tšoeu ho isa ho e tšoeu |
| Assay | 99% mets |
| Metsi | <0.5% |
| Ho potoloha ho itseng | +127 ho isa ho +139 |
| Litšepe tse boima | <20ppm |
| Masalla a ho Ignition | <0.1% |
| Litšila ka Kakaretso | <1.0% |
Tazobactam ke penicillanic acid sulfone e nang le taeo e tšoanang le ea sulbactam.Ke β-lactamaseinhibitor e matla ho feta sulbactam mme e na le ts'ebetso e pharalletseng hanyane ho feta clavulanic acid.E na le antibacterialactivity e fokolang haholo.Tazobactam e fumaneha ka tekanyo e tsitsitseng, e kopantsoeng le piperacillin, penicillin e pharaletseng e nang le tekanyo ea 8: 1 ea piperacillin sodium ho tazobactamsodium ka boima ba 'mele' me e rekisoa tlas'a lebitso la khoebo la Zosyn. Pharmacokinetics ea lithethefatsi tsena tse peli e tšoana haholo.Ka bobeli ba phela halofo e khuts'oane (t1/2 -1 hora), ba na le protheine e nyane, ba na le metabolism e nyane haholo, 'me ba ntšoa ka har'a moroto ka bongata bo phahameng.
Lipontšo tse lumelitsoeng bakeng sa piperacillin–tazobactamcombination li kenyelletsa phekolo ea appendicitis, postpartumendometritis, le lefu la ho ruruha pelvic le bakoang ke beta-lactamase-e hlahisang E. coli le Bacteroides spp., mafu a letlalo le letlalo a bakoang ke β-lactamase-producingS.aureus, le pneumonia e bakoang ke β-lactamase-producingstrains of H. influenzae.
