L-Hydroxyproline Cas: 51-35-4 phofo e tšoeu
| Nomoro ea lethathamo | XD90292 |
| Lebitso la Sehlahiswa | L-Hydroxyproline |
| CAS | 51-35-4 |
| Foromo ea limolek'hule | C5H9NO3 |
| Boima ba Molek'hule | 131.13 |
| Lintlha tsa polokelo | Ambient |
| Khoutu ea Lekhetho e Kopantsoeng | 2933998040 |
Tlhaloso ea Sehlahisoa
| Tlhahlobo | 99% |
| Ponahalo | Phofo e tšoeu |
Idiopathic pulmonary fibrosis ho nahanoa hore e kenyelletsa kotsi ea matšoafo e bakoang ke mefuta e sa tšoaneng ea oksijene (ROS), e lateloang ke fibrosis e sa tloaelehang.Ntho e fetohang ea kholo (TGF) -β1-e bakoang ke keketseho ea palo ea myofibroblast e phetha karolo ea bohlokoa ho fibrosis ena e sa tloaelehang.Haufinyane tjena re fumane hore mepenzolate bromide (mepenzolate), e 'nileng ea sebelisoa ho phekola mafu a mala, e na le thepa ea ho fokotsa ROS.Thutong ea hajoale, re hlahlobile phello ea mepenzolate ho bleomycin-induced pulmonary fibrosis le ho se sebetse ha matšoafo ho litoeba.Ho teba ha pulmonary fibrosis ho ile ha hlahlojoa ka tlhahlobo ea histopathological le boikemisetso ba maemo a hydroxyproline.Mechine ea matšoafo (elastance) le ts'ebetso ea ho hema [matla a bohlokoa a qobelloang (FVC)] li ile tsa hlahlojoa ho sebelisoa mochine o kenang o laoloang ke khomphutha.Mosebetsi oa ho hema o ile oa boela oa hlahlojoa ka ho shebella percutaneous arterial oxygen saturation (SpO2).Tsamaiso ea methapo ea mepenzolate pele ho kalafo ea bleomycin e fokolitse boholo ba pulmonary fibrosis le liphetoho mecheng ea matšoafo 'me ea lebisa ho hlaphoheloeng ho hoholo ha FVC le SpO2 ha ho bapisoa le taolo.Ho feta moo, mepenzolate e hlahisitse phello ea phekolo le ha e ne e sebelisoa ka mor'a ho hlahisa fibrosis.Tsamaiso ea mepenzolate e boetse e thibela lefu la lisele tsa pulmonary tse bakoang ke bleomycin le likarabo tsa ho ruruha le ho eketseha ha palo ea myofibroblast.Mepenzolate e boetse e fokolitse mosebetsi oa NADPH oxidase le boemo bo sebetsang ba TGF-β1 kapa ts'ebetso e eketsehileng ea glutathione S-transferase (GST) boteng ba phekolo ea bleomycin.Liphetho tsena li bontša hore tsamaiso ea intracheal ea mepenzolate e fokolitse bleomycin-induced pulmonary fibrosis le ho se sebetse ha matšoafo ho litoeba.Liphello tsena e ka 'na ea e-ba ka lebaka la phello ea thibelo ea moriana ona mesebetsing ea NADPH oxidase le TGF-β1 le phello ea eona ea stimulatory ho GST.
