D-Valine Cas: 640-68-6 C5H11NO2
| Nomoro ea lethathamo | XD90291 |
| Lebitso la Sehlahiswa | D-Valine |
| CAS | 640-68-6 |
| Foromo ea limolek'hule | C5H11NO2 |
| Boima ba Molek'hule | 117.14634 |
| Lintlha tsa polokelo | Mohaho oa Kamore |
| Khoutu ea Lekhetho e Kopantsoeng | 29224995 |
Tlhaloso ea Sehlahisoa
| Tlhahlobo | 99% |
| Ponahalo | Phofo e tšoeu |
| Botenya | 1.2000 (khakanyo) |
| Sebaka se qhibilihang | >295 °C (subl.) (lit.) |
| Ntho e belang | 213.6 °C ho 760 mmHg |
| flash point | 83℃ |
| Lenane la refractive | -27 ° (C=8, 6mol/L HCl) |
| Solubility | 56 g/L (20°C) |
| Ho qhibiliha ha metsi | 56 g/L (20 ºC) |
| PSA | 63.32000 |
| LogP | 0.75460 |
| Ho potoloha ho itseng | -27.5 º (c=5, 5N HCl) |
| Ts'ebetso ea mahlo | [α]23/D −32.0 ho −24.0°, c = 8 ho 6 M HCl |
Basali ba nang le lefu la antiphospholipid (APS) ba kotsing e kholo ea ho lahleheloa ke bokhachane khafetsa (RPL) le preeclampsia.Antiphospholipid antibodies (aPL) ka ho toba e fetola mosebetsi oa trophoblast.Kalafo e nang le heparin e tlase ea molek'hule (LMWH) e fokotsa kotsi ea RPL empa eseng preeclampsia.Ho feta moo, LMWH e susumetsa ho lokolloa ha trophoblast sFlt-1, ntho e khahlanong le angiogenic e amanang le preeclampsia.Kaha khaello ea vithamine D e amahanngoa le APS le preeclampsia, thuto ena e ne e batla ho fumana phello ea vithamine D mosebetsing oa trophoblast sebakeng sa aPL le LMWH.A human first trimester trophoblast cell line (HTR8) le litloaelo tsa mantlha tsa trophoblast li ile tsa phekoloa kapa ntle le aPL boteng le ho ba sieo ha vithamine D, LMWH kapa ka bobeli.Trophoblast secretion ea inflammatory cytokines le lintlha tsa angiogenic li ne li lekantsoe ke ELISA.Vitamin D feela kapa e kopantsoe le LMWH e ile ea fokotsa karabo ea ho ruruha ea trophoblast ea aPL ka lisele tsa HTR8 le litloaelo tse ka sehloohong.Le hoja vithamine D e ne e se na tšusumetso leha e le efe ho aPL-mediated modulation of angiogenic factor in the primary trophoblast, e ile ea thibela haholo ho lokolloa ha LMWH-induced sFlt-1. LMWH hammoho le vithamine D e ka ba molemo ho feta phekolo ea moemeli a le mong ka ho thibela aPL. -e bakoang ke ho ruruha ha trophoblast le ho khutlisetsa morao LMWH-induced sFlt-1 secretion.
