Lihlahisoa

Li-biofilms li entsoe ka lisele tsa baktheria tse kenngoeng ka har'a matrix a polymeric a iketselitseng eona.Poly-beta(1,6) -N-acetyl-d-glucosamine (PNAG) ke karolo e kholo ea biofilm matrix ho libaktheria tse fapaneng tsa phylogenetically.Thutong ena re ile ra batlisisa litšobotsi tsa 'mele le tsa lik'hemik'hale tsa PNAG matrix ka biofilms e hlahisoang ka vitro ke kokoana ea gram-negative porcine breathing pathogen Actinobacillus pleuropneumoniae le pathogen e amanang le gram-positive-e amanang le Staphylococcus epidermidis.Phello ea PNAG ho phallo ea metsi a mangata e ile ea khethoa ka ho lekanya sekhahla sa convection ea mokelikeli ka li-biofilms tse hlahisitsoeng ka lisebelisoa tsa centrifugal filter.Sekhahla sa convection ea mokelikeli se ne se phahame haholo ho li-biofilms tse hlahisitsoeng ka pel'a PNAG e senyang enzyme ea dispersin B ho feta biofilms e hlahisitsoeng ntle le enzyme, e bontšang hore PNAG e fokotsa phallo ea metsi a mangata.PNAG e boetse e thibetse ho tsamaisoa ha motsoako oa quaternary ammonium cetylpyridinium chloride (CPC) ka biofilms.Ho tlama CPC ho biofilms le ho feta ho sitisa phepelo ea mokelikeli le ho thibela ho tsamaisoa ha dae ea azo Allura e khubelu.Bioactive CPC e ile ea ntšoa ka katleho ho tsoa ho li-biofilms ka kalafo ka 1 M sodium chloride.Ha li kopane, liphuputso tsena li fana ka maikutlo a hore CPC e sebetsana ka kotloloho le matrix a PNAG mme e fetola thepa ea eona ea 'mele le ea lik'hemik'hale.Liphetho tsa rona li bontša hore PNAG e phetha karolo ea bohlokoa ho laola boemo ba 'mele ba li-biofilms' me e ka kenya letsoho lits'ebetsong tse ling tse amanang le biofilm tse kang ho hanyetsa likokoana-hloko.