Glutathione oxidized Cas: 27025-41-8 White crystalline phofo
| Nomoro ea lethathamo | XD90283 |
| Lebitso la Sehlahiswa | Glutathione oxidized |
| CAS | 27025-41-8 |
| Foromo ea limolek'hule | Setšoantšo sa C20H32N6O12S2 |
| Boima ba Molek'hule | 612.63 |
| Lintlha tsa polokelo | 2 ho isa ho 8 °C |
| Khoutu ea Lekhetho e Kopantsoeng | 2930909899 |
Tlhaloso ea Sehlahisoa
| Tlhahlobo | 99% |
| Ponahalo | Phofo e tšoeu ea kristale |
| Ho potoloha ho itseng | -96 ho ea ho -106 |
| Litšepe tse boima | 10ppm boholo |
| AS | 2ppm boholo |
| Tahlehelo ka ho Omisa | 15.0% boholo. |
| Bohloeki | 95% mets |
| Masalla a ho Ignition | 0.5% boholo |
Hepatotoxicity ea bakuli ba lithethefatsi ke e 'ngoe ea lintho tse tšoenyang haholo tlhahlobong ea lithethefatsi ha ho sibolloa lithethefatsi tsa pele.Ho lemoha khatello ea sebete ea oxidative e ka ba sesupo sa pele sa hepatotoxicity le melemo ea khetho ea lithethefatsi.The glutathione (GSH) le glutathione disulfide (GSSG) pair, e le e 'ngoe ea li-intracellular redox tse laolang banyalani, li phetha karolo ea bohlokoa ho sireletsa lisele ho tloha khatellong ea oxidative e bakoang ke ho se leka-lekane pakeng tsa prooxidants le antioxidants.Boikemisetso ba bongata ba likhakanyo tsa GSSG/GSH le likhakanyo tsa GSH le GSSG li sebelisitsoe ho bonts'a khatello ea oxidative liseleng le liseleng.Thutong ena, re lekile monyetla oa ho sebelisa likarolelano tsa biliary GSSG/GSH joalo ka biomarker ho bonahatsa khatello ea sebete ea oxidative le chefo ea lithethefatsi.Metsoako e mene e tsejoang ka ho fetola maemo a GSH le GSSG e ile ea lekoa thutong ena.Diquat (diquat dibromide monohydrate) le acetaminophen li ne li tsamaisoa ho likhoto.Paraquat le tert-butyl hydroperoxide li ne li tsamaisoa d ho litoeba ho susumetsa liphetoho tsa biliary GSH le GSSG.The biliary GSH le GSSG li ile tsa lekanyetsoa ho sebelisoa li-curve tsa calibration tse lokiselitsoeng ka bile ea maiketsetso ho ikarabella bakeng sa phello leha e le efe ea bile matrix tlhahlobong ea LC-MS le ho qoba ho kena-kenana le GSH le GSSG tse sa feleng.Ka mehlala e mene (ka likhoto le litoeba) ea liphetoho tse bakoang ke lithethefatsi ho kinetics ea biliary GSSG / GSH ratios, thuto ena e bontšitse monyetla oa ho hlahisa index ea karabo ea ho pepeseha e thehiloeng ho biliary GSSG / GSH ratios bakeng sa ho bolela esale pele khatello ea sebete ea oxidative.
