Folic Acid Cas: 59-30-3 99%
| Nomoro ea lethathamo | XD90435 |
| Lebitso la Sehlahiswa | Folic Acid |
| CAS | 59-30-3 |
| Foromo ea limolek'hule | C19H19N7O6 |
| Boima ba Molek'hule | 441.40 |
| Lintlha tsa polokelo | Ambient |
| Khoutu ea Lekhetho e Kopantsoeng | 29362900 |
Tlhaloso ea Sehlahisoa
| Ponahalo | Phofo ea kristale e mosehla kapa ea lamunu |
| Tlhahlobo | 99% |
| Metsi | 5.0 - 8.5% |
| Bohloeki ba Chromatographic | <2.0% |
| Solubility | Ha e khone ho qhibiliha ka metsing le boholo ba lihlapolli tsa tlhaho.E qhibiliha ka li-acids tse hlapollang le litharollong tsa alkaline |
| Masalla a ho Ignition | <0.3% |
Thutong ena, thermosensitive le folate functionalized poly(ethylene oxide) -b-poly(propylene oxide) -b-poly(ethylene oxide) -ploy(N-isopropylacrylamide-co-hydroxyethyl methacrylate) (FA-Pluronic-PNH) copolymer e ne e le kopantswe.Sebopeho le boima ba limolek'hule tsa copolymer li tiisitsoe ke 1H NMR, FT-IR le GPC, ka ho latellana.Mocheso o tlase oa tharollo ea bohlokoa (LCST) ea copolymer e ne e le likhato tse 39.8 C. Ka ho sebelisa doxorubicin (DOX) e le lithethefatsi tsa mohlala, li-micelles tse nang le DOX-loaded micelles tse nang le folate li ile tsa thehoa ka ho eketsehileng ho copolymer.Li-micelles tse se nang letho le tse jereng DOX ka bobeli li ne li bonts'a libopeho tse batlang li le chitja 'me bophara ba tsona bo ne bo le 35 nm le 50 nm, ka ho latellana.Mekhoa ea ho lokolloa ha in vitro ea li-micelles tse jereng DOX e ne e itšetlehile ka mocheso le tekanyo ea ho lokolloa ha DOX ho 42 degrees C (ka holimo ho LCST) e ne e le ka potlako ho feta 37 degrees C (ka tlase ho LCST).Ntle le moo, litlhahlobo tsa cytotoxicity tsa li-micelles tsa mahala tsa DOX le DOX tse jereng lisele tsa mofetše oa popelo ea HeLa le mela ea lisele tsa mofetše oa matšoafo oa motho A549 li bonts'itse hore folate e ekelitse ts'ebetso ea cellular ea li-micell ka har'a lisele tse reriloeng tse nang le li-folate receptors tse ngata haholo.
