Lihlahisoa

Bromelain (BR) ke cysteine ​​​​protease e nang le litlamorao tsa inhibitory ho secretion ea mala le ho ruruha.Leha ho le joalo, liphello tsa eona ho motility ea mala ha li e-s'o hlahlojoe.Kahoo, re ile ra batlisisa phello ea motsoako ona o entsoeng ke semela mabapi le ho kopana ha mala le ho tsamaea ka litoeba. Contractility in vitro e ile ea hlahlojoa ka ho susumetsa leamo e arohaneng le mouse, ka bateng ea setho, ka acetylcholine, barium chloride, kapa motlakase oa tšimo ea motlakase.Motility in vivo e ile ea lekanyetsoa ka ho lekola kabo ea lets'oao la fluorescent le tsamaisoang ka molomo haufi le mala a manyane.Transit e ile ea boela ea hlahlojoa linaheng tsa pathophysiologic tse hlahisitsoeng ke pro-inflammatory compound oli ea croton kapa ka diabetogenic agent streptozotocin.Bromelain e ile ea thibela li-contraction tse bakoang ke metsoako e sa tšoaneng ea spasmogenic ho ileum ea mouse e nang le matla a tšoanang.Phello ea antispasmodic e fokotsehile kapa e hanyetsanoa ke proteolytic enzyme inhibitor, gabexate (15 × 10 (-6) mol L (-1) ), protease-activated r eceptor-2 (PAR-2) mohanyetsi, N (1) -3 -methylbutyryl-N(4) -6-aminohexanoyl-piperazine (10(-4) mol L(-1) ), phospholipase C (PLC) inhibitor, neomycin (3 × 10(-3) mol L(-1) ) , le phosphodiesterase 4 (PDE4) inhibitor, rolipram (10(-6) mol L(-1) ).In vivo, BR e ile ea thibela ho tsamaea ka mokhoa o khethehileng linaheng tsa pathophysiologic ka mokhoa oa PAR-2-antagonist. lipontšo.Bromelain e ka ba motsoako o ka sehloohong bakeng sa nts'etsopele ea lithethefatsi tse ncha, tse khonang ho tloaeleha ho tsamaea ha mala ho ruruha le lefu la tsoekere.