Lihlahisoa

Ho sebetsa ha limolek'hule tsa lithibela-mafu ho phekola Pseudomonas aeruginosa pneumonia ho fokotseha ka lebaka la ho hasana ha baktheria.Ho ba teng ha litsamaiso tsa puisano tsa baktheria, joalo ka ho lemoha quorum, ho fane ka menyetla e mecha ea kalafo.Lactonase e tima ka katleho acyl-homoserine lactone-based bacterial quorum sensing, e fana ka maikutlo a hore li-enzyme tsena e ka ba litlhare tse ncha tsa anti-Pseudomonas tse ka 'nang tsa hlahlojoa ho pneumonia. ho shoa ha rat P. aeruginosa pneumonia. Ho hlahloba ho tima quorum ea SsoPox-I-mediated, re ile ra qala ka ho lekanya mosebetsi oa gene lasB ea virulence, motsoako oa pyocianin, mosebetsi oa proteolytic oa ho emisa baktheria le ho thehoa ha biofilm ea a. PAO1 e hola ka boteng ba lactonase.Ka mokhoa o bolaeang haholo oa P. aeruginosa pneumonia ho likhoto, re ile ra lekola litlamorao tsa kalafo ea pele kapa e chechisitsoeng ka har'a tracheal ka SsoPox-I mabapi le lefu, palo ea baktheria ea matšoafo le tšenyo ea matšoafo. , pyocianin synthesis, mosebetsi oa proteolytic le sebopeho sa biofilm.Tšebeliso ea pele ea SsoPox-I e ile ea fokotsa ho shoa ha likhoto tse nang le pneumonia e matla ho tloha ho 75% ho ea ho 20%.Tšenyo ea histological ea matšoafo e fokotsehile haholo empa palo ea baktheria ea matšoafo ha ea ka ea fetoloa ke kalafo.Kalafo e liehang e ne e amahanngoa le phokotso e seng ea bohlokoa ea ho shoa.Liphetho tsena li bontša liphello tse sireletsang tsa lactonase SsoPox-I ho P. aeruginosa pneumonia le ho bula tsela bakeng sa tšebeliso ea phekolo ea nakong e tlang.