Diethylene triamine pentaacetic acid Cas: 67-43-6 99% phofo e tšoeu ea kristale
| Nomoro ea lethathamo | XD90220 |
| Lebitso la Sehlahiswa | Diethylene triamine pentaacetic acid |
| CAS | 67-43-6 |
| Foromo ea limolek'hule | C14H23N3O10 |
| Boima ba Molek'hule | 393.3465 |
| Lintlha tsa polokelo | Ambient |
| Khoutu ea Lekhetho e Kopantsoeng | 29224985 |
Tlhaloso ea Sehlahisoa
| Litšepe tse boima | 0.001% boholo |
| pH | 2-3 |
| Fe | 0.001% boholo |
| Solubility | Ha e qhibilihe ka metsing, tharollo ea 15% e qhibiliha ka metsing a chesang.E qhibiliha ka har'a Alkali eohle |
| Tlhahlobo | 99% mets |
| Molora o sulfated | 0.1% boholo |
| Cl | 0.1% boholo |
| Ponahalo | Phofo e tšoeu ea kristale |
Ho eketseha ha khatello ea oxidative tlas'a maemo a hyperglycemic, ka ho sebelisana ha AGE le li-receptor tsa RAGE le ka ts'ebetso ea pontšo ea interleukin mediated transcription, ho tlalehiloe mofetše.Liphetoho tsa liprotheine li ntse li hlahlojoa bakeng sa karolo ea tsona ho nts'etsopele le tsoelo-pele ea mofets'e mme karabelo ea autoantibody khahlano le bona e ntse e fumana thahasello e le lipatlisiso tsa ho lemoha lefu lena kapele.Phuputso ena e hlahlobile liphetoho ho histone H1 ha e fetoloa ke methylglyoxal (MG) le liphello tsa eona ho auto-immunopathogenesis ea kankere.Histone e fetotsoeng e bontšitse liphetoho masala a nkhang hamonate, e fetotse tyrosine microenvironment, intermolecular cross linking le moloko oa AGEs.E bonts'itse ho pata ha li-patches tsa hydrophobic le phetoho ea hypsochromic ho fluorescence e khethehileng ea ANS.MG e na le oxidized histone H1 ka matla e lebisang ho bokelleng ha carbonyls e sebetsang.Litekanyo tse hole tsa CD tsa UV li bonts'itse ntlafatso e susumelitsoeng ke di-carbonyl ea sebopeho sa alpha le ho kenngoa ha letlapa la beta;le lithuto tsa thermal denaturation (Tm) li netefalitse botsitso ba mocheso oa histone e fetotsoeng.Tlhahlobo ea FTIR e bonts'itse phetoho ea sehlopha sa amide I, tlhahiso ea sehlopha sa carboxyethyl le li-vibrations tsa N-Cα ho histone e fetotsoeng.Tlhahlobo ea LCMS e netefalitse ho thehoa ha Nε-(carboxyethyl)lysine le lithuto tsa electron microscopic li senotse sebopeho sa amorphous aggregate.Histone e fetotsoeng e bonts'itse tlamahano ea tšebelisano e fetotsoeng le DNA.H1 e fetotsoeng e hlahisitse li-antibodies tsa titre tse phahameng ho mebutlanyana le IgG ea mofuta o ikhethileng oa sera oa mebutlanyana e kentsoeng ka H1 e fetotsoeng e bonts'a tlamahano e khethehileng le immunogen tlhahlobong ea Western Blot.IgG e arohaneng le sera sa bakuli ba nang le mofetše oa matšoafo, mofetše oa tšoelesa ea senya, mofetše oa matsoele le mofetše oa hlooho le molala o bontšitse kananelo e betere bakeng sa li-neo-epitopes ho histone e fetotsoeng, e bonts'ang boteng ba li-autoantibodies tse potolohang mofetše.Kaha litlaleho li fana ka maikutlo a kamano pakeng tsa AGE-RAGE axis le carcinogenesis, glycoxidation ea histone H1 le immunogenicity ea eona e bula litsela tsa ho utloisisa karolo ea liprotheine tsa nyutlelie tse senyehileng ka glycoxidative mofetšeng.
