D-Mannitol Cas: 69-65-8 96-101.5% phofo e tšoeu ea kristale
| Nomoro ea lethathamo | XD90226 |
| Lebitso la Sehlahiswa | D-Mannitol |
| CAS | 69-65-8 |
| Foromo ea limolek'hule | C6H14O6 |
| Boima ba Molek'hule | 182.1718 |
| Lintlha tsa polokelo | Ambient |
| Khoutu ea Lekhetho e Kopantsoeng | 29054300 |
Tlhaloso ea Sehlahisoa
| Melting Point | 164 - 169 Deg C |
| Kereiti | BP |
| Ho potoloha ho itseng | +23 - +25 |
| AS | <1ppm |
| Tahlehelo ka ho Omisa | <0.3% |
| Sulfate | <0.01% |
| Tlhahlobo | 96 - 101.5% |
| Nickel | ≤ 1ppm |
| Asiti | <0.2ml |
| Ho fokotsa Tsoekere | ≤ 0.1% |
| Boikhantšo | ⩽ 20us/cm |
| Cl | <0.007% |
| Ponahalo | Phofo e tšoeu ea kristale |
Ho batlisisa karolo ea khatello ea oxidative le/kapa ho senyeha ha mitochondrial ketsahalong ea kotsi e mpe ea liphio (AKI) nakong ea sepsis, re ile ra etsa mohlala oa in vitro o susumetsoang ke sepsis ho sebelisa lisele tsa proximal tubular epithelial tse pepesehileng ho endotoxin ea baktheria (lipopolysaccharide, LPS).Patlisiso ena e fane ka lintlha tsa bohlokoa mabapi le kamano lipakeng tsa khatello ea oxidative le bofokoli ba ketane ea phefumoloho ea mitochondrial.Kalafo ea LPS e entse hore ho be le keketseho ea polelo ea inducible nitric oxide synthase (iNOS) le NADPH oxidase 4 (NOX-4), e fana ka maikutlo a hore cytosolic overexpression ea nitric oxide le superoxide anion, mefuta e ka sehloohong ea naetrojene e sebetsang (RNS) le mefuta ea oksijene e sebetsang. (ROS).Boemo bona ba oxidant bo ne bo bonahala bo sitisa phosphorylation ea mitochondrial oxidative ka ho fokotsa ts'ebetso ea cytochrome c oxidase.Ka lebaka leo, ho ile ha e-ba le tšitiso ea lipalangoang tsa elektronike le ho pompa ha proton ho pholletsa le lera le ka hare la mitochondrial, e leng se ileng sa lebisa ho fokotseheng ha bokhoni ba lera la mitochond, ho lokolloa ha lintho tse bakang apoptotic le ho fokotseha ha adenosine triphosphate.Ho khahlisang, kamora hore e shejoe ke RNS le ROS, mitochondria le eona e ile ea fetoha moetsi oa ROS, ka hona ea kenya letsoho ho eketsa ho se sebetse ha mitochondrial.Karolo ea li-oxidants ho se sebetse ha mitochondrial e ile ea tiisoa ka ho eketsehileng ke tšebeliso ea li-iNOS inhibitors kapa li-antioxidants tse bolokang ts'ebetso ea cytochrome c oxidase le ho thibela ho senyeha ha lera la mitochondrial.Liphetho tsena li fana ka maikutlo a hore AKI e bakoang ke sepsis ha ea lokela ho nkuoa feela e le ho hloleha ha maemo a matla empa hape e le karabelo e kopaneng, ho kenyeletsoa liketsahalo tsa transcriptal, pontšo ea ROS, ts'ebetso ea mitochondrial le tšekamelo ea metabolic joalo ka apoptosis.
