Clozapine N-oxide CAS: 34233-69-7
| Nomoro ea lethathamo | XD90469 |
| Lebitso la Sehlahiswa | Clozapine N-oxide |
| CAS | 34233-69-7 |
| Foromo ea limolek'hule | C18H19ClN4O |
| Boima ba Molek'hule | 342.823 |
| Lintlha tsa polokelo | 2 ho isa ho 8 °C |
| Khoutu ea Lekhetho e Kopantsoeng | 29335990 |
Tlhaloso ea Sehlahisoa
| Melting Point | 190-248 °C |
| Ponahalo | Phofo e tšoeu |
| Tlhahlobo | 99% |
Tšusumetso e mpe e bohlokoa bakeng sa ho fana ka tsietsi ea bokhoba ba opiate joalo ka ha ho bonahatsoa ke ho ba le tlhekefetso e phahameng ea opiate e nang le bothata bo boholo ba khatello ea maikutlo (MDD).Mefuta ea litoeba e ama amygdala prodynorphin (Pdyn) e le mokena-lipakeng oa tšusumetso e mpe;leha ho le joalo, bopaki ba ho kenya letsoho ha PDYN ho amang batho hampe ho lekanyelitsoe.Mona, re fumane polelo e fokotsehileng ea PDYN mRNA ho postmortem human amygdala nucleus ea periamygdaloid cortex (PAC) ho ba hlekefetsang ba heroin le lihlooho tsa MDD.Ho tšoana le batho, likhoto tse sebelisang heroine ka nako e telele li fokolitse polelo ea Pdyn mRNA ho PAC ka nako e amanang le boemo bo bobe ba maikutlo.Re sebelisa theknoloji ea litšoantšo e sebetsang ea in vivo DREAMM (DREADD-assisted metabolic 'mapa, moo DREADD e bonts'ang li-receptors tsa moqapi li sebelisoa feela ke litlhare tsa moqapi), re fumane hore thibelo e khethiloeng ea Pdyn-expressing neurons ho rat PAC e ile ea eketsa ts'ebetso ea metabolic ho amygdala e atolositsoeng, eo. ke karolo ea bohlokoa ea tsamaiso ea khatello ea kelello ea extrahypothalamic.Ka mokhoa o ts'oanang, thibelo e khethehileng ea PAC ea Pdyn e ile ea baka liphetoho tse mpe tse amanang le 'mele le boitšoaro.Ka kakaretso, boithuto ba rona ba phetolelo bo ts'ehetsa karolo e sebetsang bakeng sa Pdyn ea nang le bokooa ho PAC tlhekefetso ea opiate ka ho kenya tšebetsong khatello ea maikutlo le ho ama neurocircuitry e amehang kotsing ea bokhoba.
