Lihlahisoa

Metabolite ea baktheria ea mala ea ginseng protopanaxadiol saponin, 20-O-(β-D-glucopyranosyl) -20(S) -protopanaxadiol (compound K), e tlalehiloe hore e baka apoptosis liseleng tse fapaneng tsa mofetše.Leha ho le joalo, mekhoa e nepahetseng e hlahisitsoeng ke motsoako oa K ka liseleng tsa hepatocellular carcinoma (HCC) e ntse e sa hlaka.E le ho hlahloba mekhoa e ka khonehang ea apoptotic, re ile ra batlisisa phello ea anticancer ea motsoako oa K ho MHCC97-H.Tlhahlobo ea MTT e bontšitse hore motsoako oa K o thibela ho ata ha lisele tsa MHCC97-H tse nang le chefo e batlang e le tlaase ho lisele tse tloaelehileng tsa hepatoma.Khatelo-pele ea potoloho ea lisele le litšila tsa sele li bontšitse keketseho ea karoloana ea apoptotic sub-G1.Kalafo ea MHCC97-H e nang le motsoako oa K le eona e bakile phokotso ea bokhoni ba membrane ea mitochondrial (Δψm) le tšenyo ea DNA.Liphuputso tse ling li bontšitse hore k'hemik'hale ea K e laola Fas, FasL, Bax / Bcl-2 karo-karolelano le ho theola pro-caspase-9, pro-caspase-3 ka mokhoa o itšetlehileng ka tekanyo, hape e thibela Akt phosphorylation.Liphetho tsena li fana ka maikutlo a hore motsoako oa K o thibela haholo ho ata ha lisele le ho etsa hore apoptosis e be liseleng tsa MHCC97-H ka litsela tse itšetlehileng ka caspase ea Fas le mitochondria liseleng tsa HCC tsa motho.