Acriflavine, Neutral Cas: 8048-52-0 Orange ho ea ho khubelu ho ea phofo e khubelu-sootho
| Nomoro ea lethathamo | XD90521 |
| Lebitso la Sehlahiswa | Acriflavine, ha e nke lehlakore |
| CAS | 8048-52-0 |
| Foromo ea limolek'hule | C14H14ClN3 |
| Boima ba Molek'hule | 259.73 |
| Lintlha tsa polokelo | Ambient |
| Khoutu ea Lekhetho e Kopantsoeng | 38249993 |
Tlhaloso ea Sehlahisoa
| Ponahalo | Orange ho ea ho khubelu ho ea ho phofo e khubelu-sootho |
| Tlhahlobo | 99% |
| AS | 10ppm boholo |
| Tahlehelo ka ho Omisa | 8% max |
| Metsi a sa qhibidihang | 0.5% boholo |
| Molora o sulfated | 3.5% boholo |
| Tekolo ea chlorine e omisitsoe ho 105 Deg C bakeng sa lihora tse peli | 13.3 - 15.8% |
Lithethefatsi tse ngata tse thibelang mofetše li hlōleha ho felisa lihlahala, e leng se lebisang ho ntlafatseng ha lithethefatsi tse hanyetsang le ho khutla ha mafu.Letšoao la Hedgehog le bapala karolo ea bohlokoa nakong ea nts'etsopele ea embryonic, empa hape e ameha kholong ea mofetše, tsoelo-pele le metastasis.Hedgehog receptor Patched (Ptc) ke mofuta oa sepheo sa Hedgehog o pepesehang haholo liseleng tse ngata tsa mofetše.Mona, re bonts'a khokahano lipakeng tsa Ptc le khanyetso ea chemotherapy, mme re fana ka temohisiso e ncha mabapi le ts'ebetso ea Ptc.Ptc e hlakoloa lera la plasma ha e sebelisana le ligand Hedgehog, kapa ha e phekoloa lisele tse nang le Hedgehog e bontšang mohanyetsi oa cyclopamine.Maemong ana ka bobeli, kamora ho kenngoa ha lisele tse nang le doxorubicin, e leng chemotherapeutic agent e sebelisoang bakeng sa taolo ea bongaka ea mofets'e o iphetang, re ile ra bona thibelo ea ho tsoa ha doxorubicin ho tsoa ho li-fibroblasts tse arabelang Hedgehog, le keketseho ea ho bokellana ha doxorubicin mofetšeng o mong o fapaneng. lisele tse tsejoang ka ho hlahisa maemo a sa tsitsang a likarolo tsa matšoao a Hedgehog.Re sebelisa mokhoa oa ho bua oa heterologous, re bontšitse ka matla hore polelo ea Ptc ea motho e fane ka khanyetso ea thibelo ea kholo ka lithethefatsi tse 'maloa tseo ho tsona li-chemotherapeutic agents tse kang doxorubicin, methotrexate, temozolomide, le 5-fluorouracil.Ho hanana le doxorubicin ho amanang le ts'ebetso ea Ptc, joalo ka ha ho bonts'itsoe ho sebelisoa liphetoho ho tsoa ho bakuli ba Gorlin's syndrome moo phello ea Ptc-mediated mabapi le pontšo ea Hedgehog e lahlehileng.Liphetho tsa rona li bonts'a hore Ptc e kenya letsoho ho felisoeng ha lithethefatsi le ho hanyetsa lithethefatsi tse ngata, 'me e fana ka maikutlo a hore Ptc e kenya letsoho ho hanyetsanang le chemotherapy liseleng tsa mofetše.
