![Bis[2-Hydroxyethyl] imino Tris-(Hydroxymethyl)-methane Cas: 6976-37-0 99% Featured Image](http://cdn.globalso.com/xdbiochems/6976-37-0.jpg)
Bis[2-Hydroxyethyl] imino Tris-(Hydroxymethyl)-methane Cas: 6976-37-0 99%
| Nomoro ea lethathamo | XD90111 |
| Lebitso la Sehlahiswa | BIS-TRIS (Bis(2-hydroxyethyl)amino-tris(hydroxymethyl)methane) |
| CAS | 6976-37-0 |
| Foromo ea limolek'hule | C8H20NO5 |
| Boima ba Molek'hule | 210.2476 |
| Lintlha tsa polokelo | Ambient |
| Khoutu ea Lekhetho e Kopantsoeng | 2922190090 |
Tlhaloso ea Sehlahisoa
| Litšepe tse boima | <10ppm |
| Masalla a ho Ignition | <0.1% |
| Pka | 6.3-6.7 |
| Ponahalo | Phofo e Tšoeu ea Crystalline |
| Solubility (1M ho H20) | E Hlakileng le e Feletseng |
| pH (1M ho H2O) | 9.0-11.0 |
| Mongobo (LOD) | 1.0% boholo. |
| Assay (Titration on dry basis) | 99.0% mets. |
Buffer, e sebelisetsoang ho lemoha creatine-creatinase;e boetse e sebelisoa bakeng sa tšireletso e sebetsang ea haemoglobin ka ho omisa ka leqhoa;catholyte, e sebelisoang ho IEF/2-D gel electrophoresis.
Glial cell line-derived neurotrophic factor (GDNF) ke inhibitor e matla ea tšebeliso ea ethanol le ho khutlela morao hape, 'me litoeba tsa GDNF heterozygous knockout li bonts'a kutloisiso ea moputso ho ethanol le ho sebelisa ethanol e ngata ka mor'a nako ea ho ila ho feta littermate tsa tsona tse hlaha.Mona, re ile ra leka hore na ethanol e fetola polelo ea GDNF sebakeng sa ventral tegmental (VTA; sebaka sa ts'ebetso sa GDNF) le / kapa nucleus accumbens (NAc; mohloli o moholo oa GDNF), 'me haeba ho joalo, fumana karolo ea ntlha ea kholo ea ho qetela. taolong ea tšebeliso ea ethanol.Tsamaiso ea tsamaiso ea ethanol e ekelitse polelo ea GDNF le maemo a protheine ho VTA, empa eseng NAc.Ho phaella moo, litekanyetso tsa GDNF li ile tsa phahamisoa ka mor'a seboka sa ho noa ethanol ho likhoto tse jang ethanol ka mokhoa oa ho fumana nako ea ho fumana libotlolo tse peli bakeng sa beke ea 1, empa eseng libeke tsa 7.Ho haelloa ka mor'a libeke tsa 7 tsa ho noa ethanol ka mokhoa o feteletseng ho fokolitse maemo a GDNF, ha nako e khutšoanyane ea ho noa ethanol ka mor'a ho lahleheloa ke polelo ea GDNF e laoloang.Habohlokoa, ho kokota ha GDNF ka har'a VTA ho sebelisa adenovirus e hlalosang moriri o mokhutšoanyane oa RNA ho nolofalitse ho eketseha ha ho noa ethanol ka likhoto tsa ethanol-naïve, empa eseng ka likhoto tse nang le histori ea tšebeliso e feteletseng ea ethanol.Liphello tsena li fana ka maikutlo a hore nakong ea liphihlelo tsa pele tsa ho noa ethanol, GDNF ho VTA e eketseha 'me e sireletsa khahlanong le nts'etsopele ea ho noa ethanol e feteletseng.Leha ho le joalo, karabelo ea tšireletso ea ntlha ea kholo ho ethanol e senyeha ka mor'a ho noa le ho tlohela ethanol ka nako e telele, e leng se bakang tšebeliso e tsitsitseng, e feteletseng ea ethanol.
