BCIP-Toluidine)5-Bromo-4-chloro-3-indolylphosphate-p-toluidine letsoai Cas:6578-06-9 99% phofo e tšoeu ho isa ho e khanyang
| Nomoro ea lethathamo | XD90137 |
| Lebitso la Sehlahiswa | BCIP-Toluidine)5-Bromo-4-chloro-3-indolylphosphate-p-toluidine letsoai |
| CAS | 6578-06-9 |
| Foromo ea limolek'hule | C8H5BrClNO4P·C7H10N |
| Boima ba Molek'hule | 433.62 |
| Lintlha tsa polokelo | -15 ho ea ho -20 ° C |
| Khoutu ea Lekhetho e Kopantsoeng | 29339980 |
Tlhaloso ea Sehlahisoa
| Ponahalo | Phofo e tšoeu/e sootho e bobebe |
| Assay | ≥ 99% |
| Sebaka se qhibilihang | 194-195 ºC |
| Ntho e belang | 580.2°C ho 760 mmHg |
| flash point | 304.7°C |
| Solubility | DMF: 20 mg/mL |
| Solubility | qhibilihang ka har'a dimethylformamide, e sa qhibiliheng metsing. |
| Kutloelo-bohloko | E na le kutloelo-bohloko ho khanya, e utloa moea, 'me e utloa mocheso |
Ts'ebetso ea baeloji: BCIP (BCIP p-toluidine letsoai; X-phosphate p-toluidine letsoai) ke karoloana ea chromogenic bakeng sa ho lemoha colorimetric ea ts'ebetso ea alkaline phosphatase.
Chefo ea Shiga (Stxs) e hlahisoa ke enterohemorrhagic Escherichia coli (EHEC), e bakang tšoaetso ea batho ka phello e atisang ho bolaea.Lisele tsa Vero cell, tse nkiloeng ho liphio tsa litšoene tse tala tsa Afrika, li emela maemo a khauta a ho khetholla litlamorao tsa cytotoxic tsa Stxs.Ho sa tsotellehe tšebeliso ea bona ea lefats'e ka bophara, tsebo e mabapi le mekhoa e nepahetseng ea Stx receptor glycosphingolipids (GSLs) le kopano ea bona ea lipid rafts e futsanehile.Mona re fana ka tlhahlobo e pharaletseng ea sebopeho sa li-Stx receptor GSL le ho ajoa ha tsona ho li-membrane tse thibelang li-detergent (DRM), tse neng li lokiselitsoe ho tloha liseleng tsa Vero-B4 'me tsa sebelisoa e le li-lipid raft tse lekanang.Re khethile globotriaosylceramide (Gb3Cer) le globotetraosylceramide (Gb4Cer) e le li-receptor tsa GSL bakeng sa li-subtypes tsa Stx1a, Stx2a, le Stx2e tse sebelisang ho lemoha ha holim'a TLC ho kopantsoe le MS.Mokelikeli o sa tloaelehang oa Stx, globopentaosylceramide (Gb5Cer, Galβ3GalNAcβ3Glα4Galβ4Glcβ1Cer), e neng e tsejoa ka ho khetheha (ho phaella ho Gb3Cer le Gb4Cer) ke Stx2e, e ne e khetholloa ka ho feletseng.Lipoforms tsa Stx receptor GSLs li ile tsa fumanoa li na le likarolo tse ngata tsa ceramide tse entsoeng ka sphingosine (d18: 1) le C24: 0 / C24: 1 kapa C16: 0 fatty acid.Ho feta moo, tšebelisano-'moho le matšoao a lipid raft, SM le cholesterol, ho li-DRM li khothalelitse ho amahanngoa le GSL le membrane microdomains.Phuputso ena e fana ka motheo oa ho hlahloba ka ho eketsehileng phello e sebetsang ea li-receptor tsa lipid raft tse amanang le Stx bakeng sa kotsi e bakoang ke chefo ea lisele tsa Vero-B4.
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