Lihlahisoa

Botenya, lefu la tsoekere la mofuta oa 2 le hyperlipidemia hangata li phela hammoho 'me li amahanngoa le ho eketseha ho hoholo ha mafu le lefu.Tšebeliso ea lik'habohaedreite tse hloekisitsoeng haholo-holo fructose e eketsehile haholo lilemong tsa morao tjena 'me e tsamaisana le ho eketseha ha botenya le lefu la tsoekere.Liphuputso tsa batho le liphoofolo li bontšitse hore ho ja fructose e ngata ho amana hantle le ho eketseha ha dyslipidemia, ho hanyetsa insulin le khatello ea mali.Metabolism ea fructose e hlaha haholo sebeteng mme phallo e phahameng ea fructose e lebisa ho bokelleng ha sebete sa triglyceride (hepatic steatosis).Sena se fella ka ho senyeha ha tsoekere le metabolism ea lipid le ho eketseha ha polelo ea proinflammatory cytokine.Mona re bonts'a hore fructose e fetola polelo ea glucose-stimulated ea activated acetyl CoA carboxylase (ACC), pSer hormone sensitive lipase (pSerHSL) le adipose triglyceride lipase (ATGL) ho HepG2 ea sebete kapa litloaelo tse ka sehloohong tsa lisele tsa sebete ka har'a vitro.Sena se ne se amahanngoa le ho eketseha ha de novo triglyceride synthesis in vitro le hepatic steatosis in vivo ho litoeba tse feptjoang ka fructose khahlano le tsoekere le lijo tse tloaelehileng.Lithuto tsena li fana ka temohisiso e ncha mabapi le mekhoa e amehang ho fructose-mediated hepatic hypertriglyceridemia le ho hlwaya fructose-uptake e le sepheo se secha sa kalafo bakeng sa mafu a amanang le lipid.