Lihlahisoa

Mokhoa o mong oa bohlokoa oa kalafo ea lefu la tsoekere la mofuta oa 2 ke tšebeliso ea li-agent tse ka fokotsang postprandial hyperglycemia ka ho thibela li-enzyme tsa tšilo ea lik'habohaedreite.Boithuto ba hona joale bo ile ba batlisisa litlamorao tsa tlhahiso ea tataiso ea bioassay le likaroloana tsa litholoana tse omisitsoeng tsa pericarp ea Phaleria macrocarpa, semela sa setso sa anti-diabetic, ho α-glucosidase le α-amylase, molemong oa ho utloisisa mokhoa oa bona oa anti-diabetic, joalo ka hammoho le khato ea bona ea ho fokotsa tsoekere ka mor'a ho ja lijo tse nang le tsoekere. bakeng sa in vitro α-glucosidase (yeast) le α-amylase (porcine) thibelo ea mosebetsi.Ho feta moo, liteko tse netefalitsoeng ka vivo li ile tsa etsoa ho likhoto tsa lefu la tsoekere tse hlahisitsoeng ke streptozotocin (SDRs) ho sebelisa liteko tsa mamello ea tsoekere, sucrose le starch. 75%) le α-amylase (87%) in vitro (IC50 = 2.40 ± 0.23 μg / ml le 58.50 ± 0.13 μg / ml, ka ho latellana) ka mokhoa o itšetlehileng ka tekanyo;phello e fumanoeng e ka ba 20% e phahameng ho feta acarbose (55%), e tloaelehileng ea α-glucosidase inhibitor (IC50 = 3.45 ± 0.19 μg / ml).ME le SFI li ile tsa boela tsa thibela α-glucosidase (IC50 = 7.50 ± 0.15 μg/ml le 11.45 ± 0.28 μg/ml) le α-amylase (IC50 = 43.90 ± 0.19 μg/ml) ± 0.80 μg/ml le 6 μg. tekanyo e nyane.Lithutong tsa in vivo tse nang le likhoto tsa lefu la tsoekere, NBF le SFI li ile tsa fokotsa tsoekere e phahameng ea mali (PBG) ka 15.08% le 6.46%, le sebaka se tlas'a tolerance curve (AUC) ka 14.23% le 12.46%, ka ho latellana, kamora phephetso ea oral sucrose. (P <0.05);ka hona ho netefatsa ts'ebetso ea in vitro e hlokometsoeng.Liphello tsena tsa phokotso ho PBG le AUC li ile tsa boela tsa bontšoa litekong tsa mamello ea tsoekere le starch, empa ka tekanyo e fokolang. semela se sebetsang bakeng sa ho fumana metsoako ea tlhaho bakeng sa taolo ea mofuta oa 2 lefu la tsoekere mellitus.