Libaktheria tsa Colonic, tse bontšitsoeng ke Bacteroides thetaiotaomicron, li phetha karolo ea bohlokoa ho boloka bophelo bo botle ba batho ka ho sebelisa malapa a maholo a glycoside hydrolases (GHs) ho sebelisa li-polysaccharides tsa lijo le ho amohela li-glycans e le limatlafatsi.Katoloso e joalo ea lelapa la GH e bonahatsoa ke lelapa la 23 la GH92 glycosidase le kentsoeng ke B. thetaiotaomicron genome.Mona re bonts'a hore tsena ke alpha-mannosidase tse sebetsang ka mokhoa o le mong oa ho falla ho sebelisa N-glycans e amohelang.Sebopeho sa mahlakore a mararo sa li-mannosidase tse peli tsa GH92 se hlalosa lelapa la liprotheine tse peli tsa li-domain moo setsi sa catalytic se fumanehang sebakeng sa marang-rang, se fana ka thuso ea acid (glutamate) le base (aspartate) ho hydrolysis ka Ca (2+) - mokgoa o itshetlehileng.Mehaho ea mahlakore a mararo ea li-GH92 tse rarahaneng tse nang le li-inhibitors li fana ka temohisiso mabapi le ho khetheha, mokhoa le ho lumellana le leeto la catalysis.Ca(2+) e bapala karolo ea bohlokoa ho thusa ho khopamisa mannoside hole le maemo a eona a tlase (4)C(1) a lebang boemo ba phetoho.
