Uridine-5'-diphosphoglucuronic acid trisodium letsoai CAS: 63700-19-6 phofo e tšoeu
| Nomoro ea lethathamo | XD90382 |
| Lebitso la Sehlahiswa | Uridine-5'-diphosphoglucuronic acid trisodium letsoai |
| CAS | 63700-19-6 |
| Foromo ea limolek'hule | C15H19N2O18P2Na3 |
| Boima ba Molek'hule | 646.20 |
| Lintlha tsa polokelo | <-4 °C |
Tlhaloso ea Sehlahisoa
| Tlhahlobo | 99% |
| Ponahalo | Phofo e tšoeu |
Boithuto ba hajoale bo ikemiselitse ho batlisisa tšusumetso ea chefo ea irinotecan ka biotransformation ea glucoaurantio-obtusin ho aurantio-obtusin.Tsamaiso ea Intraperitoneal (ip) ea 100 mg/kg aurantio-obtusin e ile ea eketsa chefo ea irinotecan haholo, empa tsamaiso ea ip ea 100 mg/kg glucoaurantio-obtusin e bontšitse tšusumetso e fokolang ho chefo ea irinotecan.Ho feta moo, mochine o ile oa hlalosoa ka ho khetholla bokhoni ba ho thibela glucoaurantio-obtusin le aurantio-obtusin mabapi le metabolism ea glucuronidation ea SN-38 e nkoang e le sehlahisoa se seholo se sebetsang se ikarabellang bakeng sa chefo ea irinotecan.Liphetho li bonts'itse hore aurantio-obtusin e bonts'itse thibelo e matla ea tlholisano ho glucuronidation ea SN-38, empa bokhoni bo sa reng letho ba glucoaurantio-obtusin ho SN-38 glucuronidation bo ile ba bonoa.Liphetho tsena li bonts'itse hore biotransformation ea glucoaurantio-obtusin ho aurantio-obtusin e ekelitse chefo ea irinotecan ka ho thibela ho eketseha ha SN-38 glucuronidation.
