Lihlahisoa

Trans-4-Amino-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid ke motsoako oa lik'hemik'hale o nang le mefuta e fapaneng ea ts'ebeliso, haholo-holo ka har'a organic synthesis le lipatlisiso tsa meriana.Sebopeho sa eona se na le selikalikoe sa pyrrolidine se nkeloang sebaka ke sehlopha sa amino le sehlopha se sireletsang tert-butoxycarbonyl (Boc) holim'a athomo ea naetrojene.E 'ngoe ea litšebeliso tsa mantlha tsa trans-4-Amino-1-(tert-butoxycarbonyl)pyrrolidine-3- asiti ea carboxylic ke motheo oa moaho oa ho kopanya limolek'hule tse rarahaneng tsa manyolo.Ho ba teng ha sehlopha sa amino ho lumella liphetoho tse ngata tsa lik'hemik'hale, ho kenyelletsa le li-amidation, acylation, kapa coupling reactions, tseo e leng tsa mantlha ho thehoeng ha metsoako e fapaneng e nang le thepa e itseng ea bongaka kapa ea lik'hemik'hale.Sehlopha se sireletsang sa Boc se sireletsa sehlopha sa amino nakong ea liketso tsena, ho thibela litšebelisano tse sa batleheng kapa liketso tse ka thōko.Ho feta moo, trans-4-Amino-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid ke ea bohlokoa ka ho khetheha ha ho etsoa peptide-based. lithethefatsi.Li-peptide ke liketane tse khutšoane tsa li-amino acid tse bapalang karolo ea bohlokoa lits'ebetsong tsa tlhaho.Ka ho khetha ho thibela sehlopha sa Boc, motsoako ona o ka sebetsa e le mohaho oa amino acid ho theha tatellano ea peptide.Sena se lumella hore ho thehoe lithethefatsi tse thehiloeng ho li-peptide, tse ka lebisang lipakane tse khethehileng tsa limolek'hule, tse kang li-receptor kapa li-enzyme, le ho fetola litsela tse fapaneng tsa likokoana-hloko.Lithethefatsi tsena li bontšitse tšepiso libakeng tse kang phekolo ea kankere, phekolo ea likokoana-hloko, le mathata a li-hormone.Ho feto-fetoha ha motsoako ho boetse ho fetela ho bokhoni ba eona e le ntho e qalang bakeng sa ho qaptjoa ha limolek'hule tse nyenyane tsa tlhaho tse nang le ts'ebetso ea likokoana-hloko.Ka ho qhekella lihlopha tse sebetsang le stereochemistry ea trans-4-Amino-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid, bafuputsi ba ka etsa li-analogues kapa li-derivatives tse nang le thepa e ntlafalitsoeng ea pharmacological.Metsoako ena e fetotsoeng e ka hlahlojoa bakeng sa batho ba ka 'nang ba e-ba le lithethefatsi, ho hlahlojoa hore na ba khona ho sebelisana le lipakane tsa likokoana-hloko, kapa ho ithutoa bakeng sa thepa ea bona ea mechine.Ho feta moo, trans-4-Amino-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid can e sebelisoe joalo ka motsoako oa litšupiso molemong oa tlhahlobo.Sebopeho sa eona se tsitsitseng le thepa e nang le mekhoa e metle e etsa hore e be ea bohlokoa e le mokhoa oa ho laola boleng ba ho etsa meriana, ho netefatsa ho nepahala le ho tšepahala ha mekhoa ea ho hlahloba e sebelisetsoang ho hlahloba bohloeki le matla a metsoako e amanang le eona. Qetellong, trans-4-Amino-1- (tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid ke motsoako o feto-fetohang o nang le ts'ebeliso ea bohlokoa ho organic synthesis le lipatlisiso tsa meriana.Sebopeho sa eona se kang amino acid le sehlopha se sireletsang se etsa hore e be sebaka sa bohlokoa sa ho aha limolek'hule tse rarahaneng tsa lintho tse phelang, ho kenyeletsoa li-peptide le batho ba ka 'nang ba e-ba le lithethefatsi.Lipatlisiso tse ntseng li tsoela pele mabapi le thepa ea eona le liphetoho li tla tsoela pele ho atolosa ts'ebeliso ea eona le ho kenya letsoho ntlafatsong ea li-agent tse ncha tsa phekolo.